Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7275
Title: Walnut supplementation increases levels of UCP1 and CD36 in brown adipose tissue independently of diet type
Authors: Dakić, Tamara 
Jeremic, Dusan
Lakić, Iva 
Jasnić, Nebojša 
Ružičić, Aleksandra 
Vujović, Predrag 
Jevđović, Tanja 
Keywords: Brown adipose tissue;Fructose;Metabolism;Walnut
Issue Date: Jul-2024
Rank: M22
Project: 451-03-65/2024-03/ 200178
451-03- 66/2024-03/ 200178
Journal: Molecular and cellular biochemistry
Volume: 479
Issue: 7
Start page: 1735
End page: 1745
Abstract: 
Dietary interventions that modulate the brown adipose tissue (BAT) thermogenic activity could represent a promising therapy for metabolic disorders. In order to examine if dietary walnuts intake regulates the expression of BAT thermogenic markers levels in healthy and metabolically challenged (fructose fed) animals, rats were initially divided into the control and fructose-fed groups. After nine weeks, these groups were subdivided into the one kept on the original regimens and the other supplemented with walnuts. High-fructose diet resulted in an increased relative BAT mass and no change in UCP1 content, while the walnut supplementation increased the amount of UCP1 in BAT, but did not affect 5-HT, NA, DHPG content and DHPG/NA ratio regardless of the diet. Moreover, the CD36 levels were increased following the walnut consumption, unlike FATP1, GLUT1, GLUT4, and glycogen content which remained unchanged. Additionally, the BAT levels of activated IR and Akt were not affected by walnut consumption, while ERK signaling was decreased. Overall, we found that walnut consumption increased UCP1 and CD36 content in the BAT of both control and metabolically challenged rats, suggesting that FFAs represent the BAT preferred substrate under the previously described circumstances. This further implies that incorporating walnuts into the everyday diet may help to alleviate some symptoms of the metabolic disorder.
URI: https://biore.bio.bg.ac.rs/handle/123456789/7275
ISSN: 03008177
DOI: 10.1007/s11010-024-04981-7
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