Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7275
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dc.contributor.authorDakić, Tamaraen_US
dc.contributor.authorJeremic, Dusanen_US
dc.contributor.authorLakić, Ivaen_US
dc.contributor.authorJasnić, Nebojšaen_US
dc.contributor.authorRužičić, Aleksandraen_US
dc.contributor.authorVujović, Predragen_US
dc.contributor.authorJevđović, Tanjaen_US
dc.date.accessioned2024-09-10T07:31:46Z-
dc.date.available2024-09-10T07:31:46Z-
dc.date.issued2024-07-
dc.identifier.issn03008177-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/7275-
dc.description.abstractDietary interventions that modulate the brown adipose tissue (BAT) thermogenic activity could represent a promising therapy for metabolic disorders. In order to examine if dietary walnuts intake regulates the expression of BAT thermogenic markers levels in healthy and metabolically challenged (fructose fed) animals, rats were initially divided into the control and fructose-fed groups. After nine weeks, these groups were subdivided into the one kept on the original regimens and the other supplemented with walnuts. High-fructose diet resulted in an increased relative BAT mass and no change in UCP1 content, while the walnut supplementation increased the amount of UCP1 in BAT, but did not affect 5-HT, NA, DHPG content and DHPG/NA ratio regardless of the diet. Moreover, the CD36 levels were increased following the walnut consumption, unlike FATP1, GLUT1, GLUT4, and glycogen content which remained unchanged. Additionally, the BAT levels of activated IR and Akt were not affected by walnut consumption, while ERK signaling was decreased. Overall, we found that walnut consumption increased UCP1 and CD36 content in the BAT of both control and metabolically challenged rats, suggesting that FFAs represent the BAT preferred substrate under the previously described circumstances. This further implies that incorporating walnuts into the everyday diet may help to alleviate some symptoms of the metabolic disorder.en_US
dc.language.isoenen_US
dc.relation451-03-65/2024-03/ 200178en_US
dc.relation451-03- 66/2024-03/ 200178en_US
dc.relation.ispartofMolecular and cellular biochemistryen_US
dc.subjectBrown adipose tissueen_US
dc.subjectFructoseen_US
dc.subjectMetabolismen_US
dc.subjectWalnuten_US
dc.titleWalnut supplementation increases levels of UCP1 and CD36 in brown adipose tissue independently of diet typeen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1007/s11010-024-04981-7-
dc.identifier.pmid38478220-
dc.identifier.scopus2-s2.0-85187699550-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85187699550-
dc.description.rankM22en_US
dc.description.impact3,5en_US
dc.description.startpage1735en_US
dc.description.endpage1745en_US
dc.description.volume479en_US
dc.description.issue7en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.orcid0000-0002-7238-2728-
crisitem.author.orcid0000-0001-8894-7300-
crisitem.author.orcid0000-0003-0333-333X-
crisitem.author.orcid0000-0002-9444-4758-
crisitem.author.orcid0000-0001-6047-9365-
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