Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/995
Title: The effects of cold acclimation and nitric oxide on antioxidative enzymes in rat pancreas
Authors: Vasilijević, A.
Buzadžić, B.
Korać, Aleksandra 
Petrović, V.
Janković, A.
Veličković, Ksenija 
Korać, Bato 
Keywords: Antioxidative defense;Cold;Nitric oxide;Pancreas;Reactive oxygen species
Issue Date: 1-May-2007
Journal: Comparative Biochemistry and Physiology - C Toxicology and Pharmacology
Abstract: 
Alterations of pancreatic antioxidative defense (AD) and possible nitric oxide (NO) role in AD organization of adult rats receiving l-arginine·HCl (2.25%) or Nω-nitro-l-arginine methyl ester (L-NAME·HCl, 0.01%) as drinking liquids and maintained at room (22 ± 1 °C) or low (4 ± 1 °C) temperature for 45 days were studied. For that purpose, copper, zinc- and manganese superoxide dismutase (CuZnSOD, MnSOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST) and glutathione reductase (GR) activities were determined. Cold-induced decrease of CuZnSOD was inhibited with L-NAME, while l-arginine produced the same effect as cold in both supplemented groups. Cold acclimation elevated GSH-Px activity. l-Arginine and L-NAME expressed no effect on GSH-Px in rats kept at room temperature. L-NAME additionally elevated cold-induced GSH-Px activity, l-arginine expressing a similar trend. Cold-induced increase in GST activity was inhibited by L-NAME, while l-arginine inhibited this enzyme in both supplemented groups. Cold acclimation increased GR activity in control and L-NAME-treated group and l-arginine expressed a similar trend. Neither of the treatments affected MnSOD and CAT activities. Cold-induced changes of pancreatic AD were additionally affected by the alterations in l-arginine-NO-producing pathway. Some AD changes in the same direction with l-arginine or L-NAME point to the complexity of nitrogen compounds metabolism and function, accompanied by tissue-specific response. © 2007 Elsevier Inc. All rights reserved.
URI: https://biore.bio.bg.ac.rs/handle/123456789/995
ISSN: 1532-0456
DOI: 10.1016/j.cbpc.2007.02.013
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