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Title: | The effects of cold acclimation and nitric oxide on antioxidative enzymes in rat pancreas | Authors: | Vasilijević, A. Buzadžić, B. Korać, Aleksandra Petrović, V. Janković, A. Veličković, Ksenija Korać, Bato |
Keywords: | Antioxidative defense;Cold;Nitric oxide;Pancreas;Reactive oxygen species | Issue Date: | 1-May-2007 | Journal: | Comparative Biochemistry and Physiology - C Toxicology and Pharmacology | Abstract: | Alterations of pancreatic antioxidative defense (AD) and possible nitric oxide (NO) role in AD organization of adult rats receiving l-arginine·HCl (2.25%) or Nω-nitro-l-arginine methyl ester (L-NAME·HCl, 0.01%) as drinking liquids and maintained at room (22 ± 1 °C) or low (4 ± 1 °C) temperature for 45 days were studied. For that purpose, copper, zinc- and manganese superoxide dismutase (CuZnSOD, MnSOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST) and glutathione reductase (GR) activities were determined. Cold-induced decrease of CuZnSOD was inhibited with L-NAME, while l-arginine produced the same effect as cold in both supplemented groups. Cold acclimation elevated GSH-Px activity. l-Arginine and L-NAME expressed no effect on GSH-Px in rats kept at room temperature. L-NAME additionally elevated cold-induced GSH-Px activity, l-arginine expressing a similar trend. Cold-induced increase in GST activity was inhibited by L-NAME, while l-arginine inhibited this enzyme in both supplemented groups. Cold acclimation increased GR activity in control and L-NAME-treated group and l-arginine expressed a similar trend. Neither of the treatments affected MnSOD and CAT activities. Cold-induced changes of pancreatic AD were additionally affected by the alterations in l-arginine-NO-producing pathway. Some AD changes in the same direction with l-arginine or L-NAME point to the complexity of nitrogen compounds metabolism and function, accompanied by tissue-specific response. © 2007 Elsevier Inc. All rights reserved. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/995 | ISSN: | 1532-0456 | DOI: | 10.1016/j.cbpc.2007.02.013 |
Appears in Collections: | Journal Article |
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