Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/995
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dc.contributor.authorVasilijević, A.en_US
dc.contributor.authorBuzadžić, B.en_US
dc.contributor.authorKorać, Aleksandraen_US
dc.contributor.authorPetrović, V.en_US
dc.contributor.authorJanković, A.en_US
dc.contributor.authorVeličković, Ksenijaen_US
dc.contributor.authorKorać, Batoen_US
dc.date.accessioned2019-07-22T08:52:57Z-
dc.date.available2019-07-22T08:52:57Z-
dc.date.issued2007-05-01-
dc.identifier.issn1532-0456-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/995-
dc.description.abstractAlterations of pancreatic antioxidative defense (AD) and possible nitric oxide (NO) role in AD organization of adult rats receiving l-arginine·HCl (2.25%) or Nω-nitro-l-arginine methyl ester (L-NAME·HCl, 0.01%) as drinking liquids and maintained at room (22 ± 1 °C) or low (4 ± 1 °C) temperature for 45 days were studied. For that purpose, copper, zinc- and manganese superoxide dismutase (CuZnSOD, MnSOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST) and glutathione reductase (GR) activities were determined. Cold-induced decrease of CuZnSOD was inhibited with L-NAME, while l-arginine produced the same effect as cold in both supplemented groups. Cold acclimation elevated GSH-Px activity. l-Arginine and L-NAME expressed no effect on GSH-Px in rats kept at room temperature. L-NAME additionally elevated cold-induced GSH-Px activity, l-arginine expressing a similar trend. Cold-induced increase in GST activity was inhibited by L-NAME, while l-arginine inhibited this enzyme in both supplemented groups. Cold acclimation increased GR activity in control and L-NAME-treated group and l-arginine expressed a similar trend. Neither of the treatments affected MnSOD and CAT activities. Cold-induced changes of pancreatic AD were additionally affected by the alterations in l-arginine-NO-producing pathway. Some AD changes in the same direction with l-arginine or L-NAME point to the complexity of nitrogen compounds metabolism and function, accompanied by tissue-specific response. © 2007 Elsevier Inc. All rights reserved.en_US
dc.language.isoenen_US
dc.relation.ispartofComparative Biochemistry and Physiology - C Toxicology and Pharmacologyen_US
dc.subjectAntioxidative defenseen_US
dc.subjectColden_US
dc.subjectNitric oxideen_US
dc.subjectPancreasen_US
dc.subjectReactive oxygen speciesen_US
dc.titleThe effects of cold acclimation and nitric oxide on antioxidative enzymes in rat pancreasen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.cbpc.2007.02.013-
dc.identifier.pmid17395542-
dc.identifier.scopus2-s2.0-34247632249-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/34247632249-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.orcid0000-0002-3044-9963-
crisitem.author.orcid0000-0002-4373-5483-
crisitem.author.orcid0000-0001-5272-579X-
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