Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/995
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Vasilijević, A. | en_US |
dc.contributor.author | Buzadžić, B. | en_US |
dc.contributor.author | Korać, Aleksandra | en_US |
dc.contributor.author | Petrović, V. | en_US |
dc.contributor.author | Janković, A. | en_US |
dc.contributor.author | Veličković, Ksenija | en_US |
dc.contributor.author | Korać, Bato | en_US |
dc.date.accessioned | 2019-07-22T08:52:57Z | - |
dc.date.available | 2019-07-22T08:52:57Z | - |
dc.date.issued | 2007-05-01 | - |
dc.identifier.issn | 1532-0456 | - |
dc.identifier.uri | https://biore.bio.bg.ac.rs/handle/123456789/995 | - |
dc.description.abstract | Alterations of pancreatic antioxidative defense (AD) and possible nitric oxide (NO) role in AD organization of adult rats receiving l-arginine·HCl (2.25%) or Nω-nitro-l-arginine methyl ester (L-NAME·HCl, 0.01%) as drinking liquids and maintained at room (22 ± 1 °C) or low (4 ± 1 °C) temperature for 45 days were studied. For that purpose, copper, zinc- and manganese superoxide dismutase (CuZnSOD, MnSOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST) and glutathione reductase (GR) activities were determined. Cold-induced decrease of CuZnSOD was inhibited with L-NAME, while l-arginine produced the same effect as cold in both supplemented groups. Cold acclimation elevated GSH-Px activity. l-Arginine and L-NAME expressed no effect on GSH-Px in rats kept at room temperature. L-NAME additionally elevated cold-induced GSH-Px activity, l-arginine expressing a similar trend. Cold-induced increase in GST activity was inhibited by L-NAME, while l-arginine inhibited this enzyme in both supplemented groups. Cold acclimation increased GR activity in control and L-NAME-treated group and l-arginine expressed a similar trend. Neither of the treatments affected MnSOD and CAT activities. Cold-induced changes of pancreatic AD were additionally affected by the alterations in l-arginine-NO-producing pathway. Some AD changes in the same direction with l-arginine or L-NAME point to the complexity of nitrogen compounds metabolism and function, accompanied by tissue-specific response. © 2007 Elsevier Inc. All rights reserved. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Comparative Biochemistry and Physiology - C Toxicology and Pharmacology | en_US |
dc.subject | Antioxidative defense | en_US |
dc.subject | Cold | en_US |
dc.subject | Nitric oxide | en_US |
dc.subject | Pancreas | en_US |
dc.subject | Reactive oxygen species | en_US |
dc.title | The effects of cold acclimation and nitric oxide on antioxidative enzymes in rat pancreas | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.cbpc.2007.02.013 | - |
dc.identifier.pmid | 17395542 | - |
dc.identifier.scopus | 2-s2.0-34247632249 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/34247632249 | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Chair of Cell and Tissue Biology | - |
crisitem.author.dept | Chair of Cell and Tissue Biology | - |
crisitem.author.orcid | 0000-0002-3044-9963 | - |
crisitem.author.orcid | 0000-0002-4373-5483 | - |
crisitem.author.orcid | 0000-0001-5272-579X | - |
Appears in Collections: | Journal Article |
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