Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/988
Title: Subchronic oral cadmium exposure exerts both stimulatory and suppressive effects on pulmonary inflammation/immune reactivity in rats
Authors: Kulas, J.
Ninkov, M.
Tucovic, D.
Popov Aleksandrov, A.
Ukropina, Mirela 
Čakić Milošević, Maja 
Mutic, J.
Kataranovski, M.
Mirkov, I.
Keywords: Rats;Oral cadmium administration;Lungs;Cytokine response
Issue Date: Jul-2019
Rank: M21
Project: Immunomodulatory effects of environmental xenobiotics and biotic factors on the populations of mouse-like rodents (173039)
Journal: Biomed Environ Sci, 2019; 32(7): 508-519.
Abstract: 
Objective The aim of this study is to investigate the effects of oral cadmium (Cd) ingestion on the pulmonary immune response.
Methods Determination of Cd content in lungs and histopathological evaluation of the tissue was
performed in rats following 30-day oral Cd administration (5 and 50 mg/L). Antioxidant enzyme defense
(superoxide dismutase and catalase), cell infiltration, and production of tumor necrosis factor (TNF) and
interferon (IFN)-γ, as well as the activity of myeloperoxidase (MPO), nitric oxide (NO), and various
cytokines [interleukin (IL)-1β, IL-6, IL-10, and IL-17] were investigated.
Results Cd caused tissue damage and cell infiltration in the lungs, and this damage was more
pronounced at higher doses. Cd deposition resulted in lung inflammation characterized by a
dose-dependent IL-1β increase in lung homogenates, increased TNF levels at both doses, and IL-6
stimulation at low doses with inhibition observed at higher doses. Cd exerted differential effects on lung
leukocytes isolated by enzyme digestion, and these effects were characterized by a lack of change in the
production of reactive oxygen and nitrogen species, an inhibition of IL-1β and TNF, and stimulation of
MPO and IFN-γ. The higher capacity of Cd-exposed lung cells to respond to the opportunistic pathogen
Staphylococcus epidermidis was demonstrated in vitro.
Conclusion The potential of ingested Cd to exert both proinflammatory and immunosuppressive
effects on pulmonary tissue inflammation and immune reactivity highlights the complex
immunomodulatory actions of this metal.
URI: https://biore.bio.bg.ac.rs/handle/123456789/988
DOI: 10.3967/bes2019.068
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