Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/988
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dc.contributor.authorKulas, J.en_US
dc.contributor.authorNinkov, M.en_US
dc.contributor.authorTucovic, D.en_US
dc.contributor.authorPopov Aleksandrov, A.en_US
dc.contributor.authorUkropina, Mirelaen_US
dc.contributor.authorČakić Milošević, Majaen_US
dc.contributor.authorMutic, J.en_US
dc.contributor.authorKataranovski, M.en_US
dc.contributor.authorMirkov, I.en_US
dc.date.accessioned2019-07-18T11:22:39Z-
dc.date.available2019-07-18T11:22:39Z-
dc.date.issued2019-07-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/988-
dc.description.abstractObjective The aim of this study is to investigate the effects of oral cadmium (Cd) ingestion on the pulmonary immune response. Methods Determination of Cd content in lungs and histopathological evaluation of the tissue was performed in rats following 30-day oral Cd administration (5 and 50 mg/L). Antioxidant enzyme defense (superoxide dismutase and catalase), cell infiltration, and production of tumor necrosis factor (TNF) and interferon (IFN)-γ, as well as the activity of myeloperoxidase (MPO), nitric oxide (NO), and various cytokines [interleukin (IL)-1β, IL-6, IL-10, and IL-17] were investigated. Results Cd caused tissue damage and cell infiltration in the lungs, and this damage was more pronounced at higher doses. Cd deposition resulted in lung inflammation characterized by a dose-dependent IL-1β increase in lung homogenates, increased TNF levels at both doses, and IL-6 stimulation at low doses with inhibition observed at higher doses. Cd exerted differential effects on lung leukocytes isolated by enzyme digestion, and these effects were characterized by a lack of change in the production of reactive oxygen and nitrogen species, an inhibition of IL-1β and TNF, and stimulation of MPO and IFN-γ. The higher capacity of Cd-exposed lung cells to respond to the opportunistic pathogen Staphylococcus epidermidis was demonstrated in vitro. Conclusion The potential of ingested Cd to exert both proinflammatory and immunosuppressive effects on pulmonary tissue inflammation and immune reactivity highlights the complex immunomodulatory actions of this metal.en_US
dc.language.isoenen_US
dc.relationImmunomodulatory effects of environmental xenobiotics and biotic factors on the populations of mouse-like rodents (173039)en_US
dc.relation.ispartofBiomed Environ Sci, 2019; 32(7): 508-519.en_US
dc.subjectRatsen_US
dc.subjectOral cadmium administrationen_US
dc.subjectLungsen_US
dc.subjectCytokine responseen_US
dc.titleSubchronic oral cadmium exposure exerts both stimulatory and suppressive effects on pulmonary inflammation/immune reactivity in ratsen_US
dc.typeArticleen_US
dc.identifier.doi10.3967/bes2019.068-
dc.description.rankM21-
dc.description.impact3.219-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.orcid0000-0001-9305-9244-
crisitem.author.orcid0000-0002-2810-2135-
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