Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/987
Title: | Effect of chlorpromazine on human and murine intracellular carboxylesterases |
Authors: | Radenović, Lidija Kartelija, G. |
Keywords: | Carboxylesterase;Chlorpromazine;Hepatocytes;Intracellular enzymatic activity;Liver damage;Neuron;Polymor-phonuclear neutrophils |
Issue Date: | 1-Apr-2004 |
Journal: | Biochemistry (Moscow) |
Abstract: | Clinical use of chlorpromazine (CPZ), an antipsychotic drug, is limited due to its hepatotoxicity. CPZ is found to inhibit In vitro intracellular carboxylesterases (CE), such as α-naphthyl acetate esterase, naphthol AS-D chloroacetate esterase, and α-naphthyl butyrate esterase in polymorphonuclear neutrophils, hepatocytes, and neuronal brain cells from mice. CPZ inhibits CE of all these cell types... |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/987 |
ISSN: | 0006-2979 |
DOI: | 10.1023/B:BIRY.0000026192.26188.b9 |
Appears in Collections: | Journal Article |
Files in This Item:
File | Description | Size | Format | Existing users please |
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50 Effect of Chlorpromazine on Human and Murine.pdf | 530.93 kB | Adobe PDF | Request a copy |
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