Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/987
Title: Effect of chlorpromazine on human and murine intracellular carboxylesterases
Authors: Radenović, Lidija 
Kartelija, G.
Keywords: Carboxylesterase;Chlorpromazine;Hepatocytes;Intracellular enzymatic activity;Liver damage;Neuron;Polymor-phonuclear neutrophils
Issue Date: 1-Apr-2004
Journal: Biochemistry (Moscow)
Abstract: 
Clinical use of chlorpromazine (CPZ), an antipsychotic drug, is limited due to its hepatotoxicity. CPZ is found to inhibit In vitro intracellular carboxylesterases (CE), such as α-naphthyl acetate esterase, naphthol AS-D chloroacetate esterase, and α-naphthyl butyrate esterase in polymorphonuclear neutrophils, hepatocytes, and neuronal brain cells from mice. CPZ inhibits CE of all these cell types, whereby the degree of the inhibition depends on the incubation time and CPZ concentration. The polymorphonuclear neutrophils are most sensitive to CPZ. Comparable results were obtained with polymorphonuclear neutrophils from mice and humans. Since leukocytes are much more available than hepatocytes or neuronal cells in humans, we assume that CE in peripheral blood leukocytes (neutrophils and monocytes) can be used as markers for indication of pending liver damage by CPZ.
URI: https://biore.bio.bg.ac.rs/handle/123456789/987
ISSN: 0006-2979
DOI: 10.1023/B:BIRY.0000026192.26188.b9
Appears in Collections:Journal Article

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