Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/987
Title: Effect of chlorpromazine on human and murine intracellular carboxylesterases
Authors: Radenović, Lidija 
Kartelija, G.
Keywords: Carboxylesterase;Chlorpromazine;Hepatocytes;Intracellular enzymatic activity;Liver damage;Neuron;Polymor-phonuclear neutrophils
Issue Date: 1-Apr-2004
Journal: Biochemistry (Moscow)
Abstract: 
Clinical use of chlorpromazine (CPZ), an antipsychotic drug, is limited due to its hepatotoxicity. CPZ is found to inhibit In vitro intracellular carboxylesterases (CE), such as α-naphthyl acetate esterase, naphthol AS-D chloroacetate esterase, and α-naphthyl butyrate esterase in polymorphonuclear neutrophils, hepatocytes, and neuronal brain cells from mice. CPZ inhibits CE of all these cell types...
URI: https://biore.bio.bg.ac.rs/handle/123456789/987
ISSN: 0006-2979
DOI: 10.1023/B:BIRY.0000026192.26188.b9
Appears in Collections:Journal Article

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