Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/983
Title: 7-Nitroindazole reduces nitrite concentration in rat brain after intrahippocampal kainate-induced seizure
Authors: Radenović, Lidija 
Vasiljevic, Ivana
Selakovic, Vesna
Jovanovic, Marina
Keywords: 7-Nitroindazole;Brain;Glutamate receptors;Hippocampus;Kainate;Neurological disorders;Neuroprotection;Neurotoxicity;Nitric oxide;Nitrite
Issue Date: 1-Jan-2003
Journal: Comparative Biochemistry and Physiology - C Toxicology and Pharmacology
Abstract: 
Kainic acid is an endogenous excitotoxin acting on glutamate receptors, that leads to neurotoxic damage resembling the alterations observed in some neurological disorders. Stimulation of glutamate receptors induces neuronal nitric oxide (NO) release, which in turn modulates glutamate transmission. NO may be a key mediator of excitotoxic neuronal injury in the central nervous system. We investigated the effects of 7-nitroindazole, a selective neuronal nitric oxide synthase inhibitor in vivo, on nitrite concentration after kainic acid injection (0.6 mg/ml, pH 7.2) unilaterally into the CA3 region of the rat hippocampus. The accumulation of nitrite, the stable metabolite of NO, was measured by the Griess reaction at different times (5 min, 15 min, 2 h, 48 h and 7 days) following kainate injection in the ipsilateral and contralateral hippocampus, forebrain cortex, striatum and cerebellum homogenates. 7-Nitroindazole (100 μM) can effectively inhibit NO synthesis in rat brain after kainate-induced intrahippocampal neurotoxicity and suppressed nitrite accumulation. The present results suggest that neuronal NO synthase inhibitors may be useful in the treatment of neurological diseases where excitotoxic mechanisms play a role. © 2003 Elsevier Inc. All rights reserved.
URI: https://biore.bio.bg.ac.rs/handle/123456789/983
ISSN: 1532-0456
DOI: 10.1016/S1532-0456(03)00150-9
Appears in Collections:Journal Article

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