Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/972
Title: Time course of motor behavior changes in Mongolian gerbils submitted to different durations of cerebral ischemia
Authors: Janać, Branka
Radenović, Lidija 
Selaković, Vesna
Prolić, Zlatko
Keywords: Cerebral ischemia;Gerbils;Locomotion;Open field;Rearing;Rotation;Stereotypy
Issue Date: 15-Dec-2006
Journal: Behavioural Brain Research
Abstract: 
In addition to morphological changes, global cerebral ischemia leads to functional changes that can be assessed by behavioral examination. The purpose of this study was to investigate the impact of the duration of global cerebral ischemia on the time course of a comprehensive set of motor behaviors in Mongolian gerbils. The common carotid arteries of gerbils were occluded either for 5 min, 10 min, or 15 min. Gerbil motor behavior was recorded in the open field at 24 h, 48 h, 4 days, 7 days, 14 days, 21 days, and 28 days after reperfusion. Each session lasted for 60 min and was composed of six intervals of 10 min. Our results revealed that ischemic gerbils quickly develop locomotor and stereotypic hyperactivity, with the expected decrease of resting time. The most evident effect was observed in gerbils submitted to a 15 min ischemia, whose locomotor activity returned to nearly normal values after 7 days. In contrast, the duration of global cerebral ischemia had no effects on rearing, clockwise, or counter-clockwise rotation. These findings indicate that exposure to global cerebral ischemia induces changes in locomotion, stereotypy, and resting time. The magnitude and duration of these effects depend on the duration of ischemia. © 2006 Elsevier B.V. All rights reserved.
URI: https://biore.bio.bg.ac.rs/handle/123456789/972
ISSN: 0166-4328
DOI: 10.1016/j.bbr.2006.09.008
Appears in Collections:Journal Article

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