Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/951
Title: Effect of continuous exposure to alternating magnetic field (50 Hz, 0.5 mT) on serotonin and dopamine receptors activity in rat brain
Authors: Janać, Branka
Tovilović, Gordana
Tomić, Mirko
Prolić, Zlatko
Radenović, Lidija 
Keywords: 50 Hz magnetic field;Brain;Dopamine D and D receptors 1 2;Rats;Serotonin 5-HT receptors 2a
Issue Date: 1-Dec-2009
Journal: General Physiology and Biophysics
Abstract: 
External magnetic fields (MFs) have the ability to modify motor activity of animals, complex type of behaviour connected with dopaminergic and serotonergic neurotransmissions in the brain. Thus, the purpose of this study was to examine MF-induced changes in the activity of serotonin 5-HT2A receptors in the prefrontal cortex, as well as dopamine D1 and D2 receptors in the striatum of adult Wistar rats, considering their involvement in motor behavior regulation. Experimental animals were continuously exposed to extremely low frequency MF (ELF-MF, 50 Hz, 0.5 mT) for 1, 3, and 7 days. Subsequently, binding properties (Kd and Bmax) of receptors were determined by in vitro radioligand receptor binding assays. It was shown that the affinity of serotonin 5-HT2A receptors decreased and their density increased in the prefrontal cortex of rats after ELF-MF exposure. Regarding affinity, this effect was duration-dependent and most prominent after 7-day of ELF-MF exposure. In contrast to serotonin 5-HT 2A receptors in the prefrontal cortex, ELF-MF had no significant effect on the affinity and density of dopamine D1 and D2 receptors in the striatum. We can conclude that continuous exposure to ELF-MF up to 7 days affects cortical serotonergic neurotransmission, whereby intensity of these changes depends on ELF-MF exposure duration.
URI: https://biore.bio.bg.ac.rs/handle/123456789/951
ISSN: 0231-5882
Appears in Collections:Journal Article

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