Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/936
Title: Protective effect of olive leaf extract on hippocampal injury induced by transient global cerebral ischemia and reperfusion in Mongolian gerbils
Authors: Dekanski, Dragana
Selaković, Vesna
Piperski, Vesna
Radulović, Željka
Korenić, Andrej 
Radenović, Lidija 
Keywords: Gerbils;Hippocampus;Neuroprotective effects;Olive leaf;Oxidative stress
Issue Date: 15-Oct-2011
Journal: Phytomedicine
Abstract: 
The beneficial effects of antioxidant nutrients, as well as complex plant extracts, in cerebral ischemia/reperfusion brain injury are well known. Mediterranean diet, rich in olive products, is associated with lower incidence of cardiovascular disease, cancer, inflammation and stroke. In this study, the possible neuroprotective effect of standardized dry olive leaf extract (OLE) is investigated for the first time. Transient global cerebral ischemia in Mongolian gerbils was used to investigate the OLE effects on different parameters of oxidative stress and neuronal damage in hippocampus. The biochemical measurements took place at different time points (80 min, 2, 4 and 24 h) after reperfusion. The effects of applied OLE were compared with effects of quercetin, a known neuroprotective plant flavonoid. Pretreatment with OLE (100 mg/kg, per os) significantly inhibited production of superoxide and nitric oxide, decreased lipid peroxidation, and increased superoxide dismutase activity in all time points examined. Furthermore, OLE offered histological improvement as seen by decreasing neuronal damage in CA1 region of hippocampus. The effects of applied OLE were significantly higher than effects of quercetin (100 mg/kg, per os). Our results indicate that OLE exerts a potent neuroprotective activity against neuronal damage in hippocampus after transient global cerebral ischemia, which could be attributed to its antioxidative properties. © 2011 Elsevier GmbH.
URI: https://biore.bio.bg.ac.rs/handle/123456789/936
ISSN: 0944-7113
DOI: 10.1016/j.phymed.2011.05.010
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