Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7256
Title: From Molecular Mechanisms to Clinical Therapy: Understanding Sepsis-Induced Multiple Organ Dysfunction
Authors: Srdić, Tijana 
Đurašević, Siniša 
Lakić, Iva 
Ružičić, Aleksandra 
Vujović, Predrag 
Jevđović, Tanja 
Dakić, Tamara 
Đorđević, Jelena 
Tosti, Tomislav
Glumac, Sofija
Todorović, Zoran
Jasnić, Nebojša 
Keywords: gut microbiota;herbal extracts;melatonin;metformin;multiple organ failure;palmitoylethanolamide (PEA);sepsis;sepsis treatment
Issue Date: 16-Jul-2024
Rank: M21
Publisher: MDPI
Project: 451-03-65/2024-03/200178
451-03-66/2024-03/200178
451-03-66/2024-03/200026
451-03-66/2024-03/200110
Journal: International journal of molecular sciences
Volume: 25
Issue: 14
Start page: 7770
Abstract: 
Sepsis-induced multiple organ dysfunction arises from the highly complex pathophysiology encompassing the interplay of inflammation, oxidative stress, endothelial dysfunction, mitochondrial damage, cellular energy failure, and dysbiosis. Over the past decades, numerous studies have been dedicated to elucidating the underlying molecular mechanisms of sepsis in order to develop effective treatments. Current research underscores liver and cardiac dysfunction, along with acute lung and kidney injuries, as predominant causes of mortality in sepsis patients. This understanding of sepsis-induced organ failure unveils potential therapeutic targets for sepsis treatment. Various novel therapeutics, including melatonin, metformin, palmitoylethanolamide (PEA), certain herbal extracts, and gut microbiota modulators, have demonstrated efficacy in different sepsis models. In recent years, the research focus has shifted from anti-inflammatory and antioxidative agents to exploring the modulation of energy metabolism and gut microbiota in sepsis. These approaches have shown a significant impact in preventing multiple organ damage and mortality in various animal sepsis models but require further clinical investigation. The accumulation of this knowledge enriches our understanding of sepsis and is anticipated to facilitate the development of effective therapeutic strategies in the future.
URI: https://biore.bio.bg.ac.rs/handle/123456789/7256
ISSN: 1422-0067
DOI: 10.3390/ijms25147770
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