Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/6806
Title: Novel probiotic approach affetcs circulating leptin, ghrelin and interleukin-6 concentrations in obese women
Authors: Okuka, Nina
Ivanović, Nevena
Milinković, Neda
Veličković, Ksenija 
Đorđević, Brižita
Keywords: obesity;probiotics;inflammatory cytokines
Issue Date: 9-Nov-2023
Rank: М64
Publisher: Komora magistara farmacije Bosne i Hercegovine
Project: Ministry of Education, Science, and Technological Development, the Republic of Serbia - bilateral project with Austria
Related Publication(s): Abstract book „Competencies of pharmacists – from drug design to successful disease treatment“
Start page: 78
End page: 79
Conference: 5th Congress of Pharmacists of Bosnia and Herzegovina with International participation
Abstract: 
INTRODUCTION AND OBJECTIVE
Obesity is a state strongly associated with low-grade inflammation, when adipose
tissue products an array of inflammatory cytokines. Studies showed that probiotics can
have a pivotal effect on the modulation of immune and inflammatory response. We
assessed relationships between leptin, adiponectin, ghrelin, interleukin (IL)-6, and
Body Mass Index (BMI) after the intervention with novel probiotic approach.
METHODS
Fourty-seven overweight (BMI = 25.0 - 29.9 kg/m2) and obese (BMI ≥ 30.0 kg/m2)
women participated in double-blind randomized placebo-controlled trial (RCT). They
were randomly assigned to receive one capsule daily of probiotics (7x1010 CFU
Lactobacillus plantarum 299v (DSM9843), 5x109 CFU Saccharomyces cerevisiae var.
boulardii and 40 mg octacosanol; intervention group, N=24) or placebo (N=23) for three
months. Circulating concentrations of leptin, adiponectin, ghrelin and IL-6 were
measured by enzyme-linked immunosorbent assay.
RESULTS
In the intervention group, we found positive correlation between circulating levels of
leptin and IL-6 (r = 0.586, p = 0.003). In contrast, circulating concentrations of ghrelin
negatively correlated with leptin (r = -0.422, p = 0.045). In the placebo group,
correlations have not been observed.
CONCLUSIONS
79
Our study showed significant correlations between leptin an IL-6 and ghrelin,
parameters altered in obesity. More precisely, after the intervention with novel probiotic
approach, participants with decreased levels of leptin, had lower levels of IL-6 and
higher levels of ghrelin. These findings suggest that probiotics could be cosidered as
adjuvant therapy for obesity.
URI: https://biore.bio.bg.ac.rs/handle/123456789/6806
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