Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/6742
Title: Effects of cisplatin on lipid peroxidation and glutathione redox status in the liver of male rats: Protective role of selenium
Authors: Trbojević, Ivana 
Ognjanović, Branka
Đorđević, Nataša
Marković, Snežana
Štajn, A.Š.
Gavrić, Jelena
Saičić, Zorica
Keywords: Cisplatin;;Selenium;;Lipid peroxidation;;Glutathione redox status;;Liver;;Rat.
Issue Date: 2010
Rank: M23
Publisher: Srpsko biološko društvo i grupa naučnih instituta
Journal: Archives of Biological Sciences
Volume: 62
Issue: 1
Start page: 85
End page: 82
Abstract: 
The role of oxidative stress in cisplatin (CP) toxicity and its prevention by pretreatment with selenium (Se) was investigated. Male Wistar albino rats were injected with a single dose of cisplatin (7.5 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m, as Na2SeO3, i.p.) alone or in combination. The results suggest that CP intoxication induces oxidative stress and alters the glutathione redox status: reduced glutathione (GSH), oxidized glutathione (GSSG) and the GSH/GSSG ratio (GSH RI), resulting in increased lipid peroxidation (LPO) in rat liver. The pretreatment with selenium prior to CP treatment showed a protective effect against the toxic influence of CP on peroxidation of the membrane lipids and an altering of the glutathione redox status in the liver of rats. From our results we conclude that selenium functions as a potent antioxidant and suggest that it can control CP-induced hepatotoxicity in rats.
URI: https://biore.bio.bg.ac.rs/handle/123456789/6742
DOI: 10.2298/ABS1001085T
Appears in Collections:Journal Article

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