Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/6742
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dc.contributor.authorTrbojević, Ivanaen_US
dc.contributor.authorOgnjanović, Brankaen_US
dc.contributor.authorĐorđević, Natašaen_US
dc.contributor.authorMarković, Snežanaen_US
dc.contributor.authorŠtajn, A.Š.en_US
dc.contributor.authorGavrić, Jelenaen_US
dc.contributor.authorSaičić, Zoricaen_US
dc.date.accessioned2023-11-27T11:57:26Z-
dc.date.available2023-11-27T11:57:26Z-
dc.date.issued2010-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/6742-
dc.description.abstractThe role of oxidative stress in cisplatin (CP) toxicity and its prevention by pretreatment with selenium (Se) was investigated. Male Wistar albino rats were injected with a single dose of cisplatin (7.5 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m, as Na2SeO3, i.p.) alone or in combination. The results suggest that CP intoxication induces oxidative stress and alters the glutathione redox status: reduced glutathione (GSH), oxidized glutathione (GSSG) and the GSH/GSSG ratio (GSH RI), resulting in increased lipid peroxidation (LPO) in rat liver. The pretreatment with selenium prior to CP treatment showed a protective effect against the toxic influence of CP on peroxidation of the membrane lipids and an altering of the glutathione redox status in the liver of rats. From our results we conclude that selenium functions as a potent antioxidant and suggest that it can control CP-induced hepatotoxicity in rats.en_US
dc.publisherSrpsko biološko društvo i grupa naučnih institutaen_US
dc.relation.ispartofArchives of Biological Sciencesen_US
dc.subjectCisplatin;en_US
dc.subjectSelenium;en_US
dc.subjectLipid peroxidation;en_US
dc.subjectGlutathione redox status;en_US
dc.subjectLiver;en_US
dc.subjectRat.en_US
dc.titleEffects of cisplatin on lipid peroxidation and glutathione redox status in the liver of male rats: Protective role of seleniumen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.2298/ABS1001085T-
dc.description.rankM23en_US
dc.description.impact0.356en_US
dc.description.startpage85en_US
dc.description.endpage82en_US
dc.relation.issn0354-4664en_US
dc.description.volume62en_US
dc.description.issue1en_US
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Algology, Mycology and Lichenology-
crisitem.author.orcid0000-0002-6715-8422-
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