Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/6239
Title: Gastrin-producing G cells of gastric mucosa in dexamethasone-treated rats
Authors: Glišić, Radmila
Čakić-Milošević, Maja 
Ukropina, Mirela 
Marković, Stefan
Marin, Marija 
Stanković, Vesna
Keywords: Dexamethasone;;Gastrin;;Antrum;;Rats.
Issue Date: 7-Jul-2023
Rank: M24
Publisher: University of Kragujevac - Faculty of Science, Kragujevac
Journal: Kragujevac Journal of Science
Volume: 45
Start page: 195
End page: 206
Abstract: 
The systemic administration of glucocorticoids has not only strong beneficial anti-inflammatory and immunosuppressive effects but also numerous adverse health effects. Therefore, this study aimed to investigate the stereological and ultrastructural characteristics and distribution of gastrin-producing G cells in rat antral mucosa after 12 days of intraperitoneal administration of 2 mg/kg dexamethasone (DEX). In both groups of rats (DEX and control), the G cells were located at the base of the antral mucosal crypts, but in the DEX-treated rats, they were also found near the gastric lumen and showed an altered morphology compared to the basal cells. There were significant differences in the number of G cells per unit area and unit volume of antral mucosa between the groups studied. In the DEX-treated rats, the modified morphology and position of the antral G cells within the gastric units indicate their modified activity and possible impaired regulation of gastric acid production.
URI: https://biore.bio.bg.ac.rs/handle/123456789/6239
DOI: 10.5937/KgJSci2345195G
Appears in Collections:Journal Article

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