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Title: | Gastrin-producing G cells of gastric mucosa in dexamethasone-treated rats | Authors: | Glišić, Radmila Čakić-Milošević, Maja Ukropina, Mirela Marković, Stefan Marin, Marija Stanković, Vesna |
Keywords: | Dexamethasone;;Gastrin;;Antrum;;Rats. | Issue Date: | 7-Jul-2023 | Rank: | M24 | Publisher: | University of Kragujevac - Faculty of Science, Kragujevac | Journal: | Kragujevac Journal of Science | Volume: | 45 | Start page: | 195 | End page: | 206 | Abstract: | The systemic administration of glucocorticoids has not only strong beneficial anti-inflammatory and immunosuppressive effects but also numerous adverse health effects. Therefore, this study aimed to investigate the stereological and ultrastructural characteristics and distribution of gastrin-producing G cells in rat antral mucosa after 12 days of intraperitoneal administration of 2 mg/kg dexamethasone (DEX). In both groups of rats (DEX and control), the G cells were located at the base of the antral mucosal crypts, but in the DEX-treated rats, they were also found near the gastric lumen and showed an altered morphology compared to the basal cells. There were significant differences in the number of G cells per unit area and unit volume of antral mucosa between the groups studied. In the DEX-treated rats, the modified morphology and position of the antral G cells within the gastric units indicate their modified activity and possible impaired regulation of gastric acid production. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/6239 | DOI: | 10.5937/KgJSci2345195G |
Appears in Collections: | Journal Article |
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