Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/6238
Title: Histological, ultrastructural and stereological analyses of pancreatic islets in glucocorticoid-treated rats
Authors: Glišić, Radmila
Čakić-Milošević, Maja 
Ukropina, Mirela 
Mitrovski Bogdanović, Ana
Stanković, Vesna
Keywords: Pancreas;;Islet;;Dexamethasone;;Rat;;Histology;;Stereology.
Issue Date: 7-Jul-2023
Rank: M24
Publisher: University of Kragujevac - Faculty of Science, Kragujevac
Journal: Kragujevac Journal of Science
Volume: 45
Start page: 179
End page: 194
Abstract: 
Dexamethasone is a synthetic glucocorticoid commonly used in both human and veterinary medicine. Prolonged treatment with dexamethasone can lead to serious metabolic side effects such as insulin resistance and diabetes. In this study, the morphological, immunohistochemical, and ultrastructural changes in the rat pancreatic islets were investigated after dexamethasone treatment (2 mg/kg, intraperitoneally for 12 days). The results showed that the volume density, mean diameter and profile area of islets were significantly increased in dexamethasone-treated animals. The volume density, profile area and mass of B-cells increased, whereas the volume density of A-and D-cells decreased, as did the number of A-cells per mm 2 of islet. Mild insulin immunopositivity of the centrally located B-cells together with altered ultrastructural features indicated their loss of function. The results of the present study suggest adverse effects of dexamethasone on pancreatic endocrine function that may ultimately seriously affect glucose homeostasis.
URI: https://biore.bio.bg.ac.rs/handle/123456789/6238
DOI: 10.5937/KgJSci2345179G
Appears in Collections:Journal Article

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