Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/6238
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dc.contributor.authorGlišić, Radmilaen_US
dc.contributor.authorČakić-Milošević, Majaen_US
dc.contributor.authorUkropina, Mirelaen_US
dc.contributor.authorMitrovski Bogdanović, Anaen_US
dc.contributor.authorStanković, Vesnaen_US
dc.date.accessioned2023-09-13T08:30:48Z-
dc.date.available2023-09-13T08:30:48Z-
dc.date.issued2023-07-07-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/6238-
dc.description.abstractDexamethasone is a synthetic glucocorticoid commonly used in both human and veterinary medicine. Prolonged treatment with dexamethasone can lead to serious metabolic side effects such as insulin resistance and diabetes. In this study, the morphological, immunohistochemical, and ultrastructural changes in the rat pancreatic islets were investigated after dexamethasone treatment (2 mg/kg, intraperitoneally for 12 days). The results showed that the volume density, mean diameter and profile area of islets were significantly increased in dexamethasone-treated animals. The volume density, profile area and mass of B-cells increased, whereas the volume density of A-and D-cells decreased, as did the number of A-cells per mm 2 of islet. Mild insulin immunopositivity of the centrally located B-cells together with altered ultrastructural features indicated their loss of function. The results of the present study suggest adverse effects of dexamethasone on pancreatic endocrine function that may ultimately seriously affect glucose homeostasis.en_US
dc.language.isoenen_US
dc.publisherUniversity of Kragujevac - Faculty of Science, Kragujevacen_US
dc.relation.ispartofKragujevac Journal of Scienceen_US
dc.subjectPancreas;en_US
dc.subjectIslet;en_US
dc.subjectDexamethasone;en_US
dc.subjectRat;en_US
dc.subjectHistology;en_US
dc.subjectStereology.en_US
dc.titleHistological, ultrastructural and stereological analyses of pancreatic islets in glucocorticoid-treated ratsen_US
dc.typeArticleen_US
dc.identifier.doi10.5937/KgJSci2345179G-
dc.description.rankM24en_US
dc.description.startpage179en_US
dc.description.endpage194en_US
dc.relation.issn1450-9636en_US
dc.description.volume45en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.orcid0000-0002-2810-2135-
crisitem.author.orcid0000-0001-9305-9244-
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