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https://biore.bio.bg.ac.rs/handle/123456789/6228
Title: | Anti-inflammatory potency of novel ecto-5′-nucleotidase/CD73 inhibitors in astrocyte culture model of neuroinflammation |
Authors: | Mihajlović, Katarina Adzić Bukvić, Marija Dragić, Milorad Scortichini, Mirko Jacobson, Kenneth A. Nedeljković, Nadežda |
Keywords: | Astrocytes;;Cell migration;;Cytosine-based nucleoside 5'-α,β-methylene diphosphates;;Ecto-5′-nucleotidase/CD73;;Shedding. |
Issue Date: | 2-Aug-2023 |
Rank: | M21 |
Publisher: | National Library of Medicine |
Journal: | European Journal of Pharmacology |
Volume: | 956 |
Start page: | 175943 |
Abstract: | Three novel cytosine-derived α,β-methylene diphosphonates designated MRS4598, MRS4552, and MRS4602 were tested in the range of 1 × 10-9 to 1 × 10-3 M for their efficacy and potency in inhibiting membrane-bound ecto-5'-nucleotidase/CD73 activity in primary astrocytes in vitro. The compounds were also tested for their ability to attenuate the reactive astrocyte phenotype induced by proinflammatory c... |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/6228 |
DOI: | 10.1016/j.ejphar.2023.175943 |
Appears in Collections: | Journal Article |
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