Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4587
Title: l-Arginine Induces White Adipose Tissue Browning—A New Pharmaceutical Alternative to Cold
Authors: Kalezic, Andjelika
Korać, Aleksandra 
Korać, Bato 
Jankovic, Aleksandra.
Keywords: Nitric oxide;L-arginine;Browning
Issue Date: 28-Jun-2022
Rank: M21a
Publisher: MDPI
Journal: Pharmaceutics
Volume: 14
Issue: 7
Start page: 1368
Abstract: 
The beneficial effects of l-arginine supplementation in obesity and type II diabetes involve white adipose tissue (WAT) reduction and increased substrate oxidation. We aimed to test the potential of l-arginine to induce WAT browning. Therefore, the molecular basis of browning was investigated in retroperitoneal WAT (rpWAT) of rats exposed to cold or treated with 2.25% l-arginine for 1, 3, and 7 days. Compared to untreated control, levels of inducible nitric oxide (NO) synthase protein expression and NO signaling increased in both cold-exposed and l-arginine-treated groups. These increases coincided with the appearance of multilocular adipocytes and increased expression levels of uncoupling protein 1 (UCP1), thermogenic and beige adipocyte-specific genes (Cidea, Cd137, and Tmem26), mitochondriogenesis markers (peroxisome proliferator-activated receptor (PPAR)-γ coactivator-1α, mitochondrial DNA copy number), nuclear respiratory factor 1, PPARα and their respective downstream lipid oxidation enzymes after l-arginine treatment. Such browning phenotype in the l-arginine-treated group was concordant with end-course decreases in leptinaemia, rpWAT mass, and body weight. In conclusion, l-arginine mimics cold-mediated increases in NO signaling in rpWAT and induces molecular and structural fingerprints of rpWAT browning. The results endorse l-arginine as a pharmaceutical alternative to cold exposure, which could be of great interest in obesity and associated metabolic diseases.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4587
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics14071368
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