Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4587
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dc.contributor.authorKalezic, Andjelikaen_US
dc.contributor.authorKorać, Aleksandraen_US
dc.contributor.authorKorać, Batoen_US
dc.contributor.authorJankovic, Aleksandra.en_US
dc.date.accessioned2022-07-06T16:25:22Z-
dc.date.available2022-07-06T16:25:22Z-
dc.date.issued2022-06-28-
dc.identifier.issn1999-4923-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/4587-
dc.description.abstractThe beneficial effects of l-arginine supplementation in obesity and type II diabetes involve white adipose tissue (WAT) reduction and increased substrate oxidation. We aimed to test the potential of l-arginine to induce WAT browning. Therefore, the molecular basis of browning was investigated in retroperitoneal WAT (rpWAT) of rats exposed to cold or treated with 2.25% l-arginine for 1, 3, and 7 days. Compared to untreated control, levels of inducible nitric oxide (NO) synthase protein expression and NO signaling increased in both cold-exposed and l-arginine-treated groups. These increases coincided with the appearance of multilocular adipocytes and increased expression levels of uncoupling protein 1 (UCP1), thermogenic and beige adipocyte-specific genes (Cidea, Cd137, and Tmem26), mitochondriogenesis markers (peroxisome proliferator-activated receptor (PPAR)-γ coactivator-1α, mitochondrial DNA copy number), nuclear respiratory factor 1, PPARα and their respective downstream lipid oxidation enzymes after l-arginine treatment. Such browning phenotype in the l-arginine-treated group was concordant with end-course decreases in leptinaemia, rpWAT mass, and body weight. In conclusion, l-arginine mimics cold-mediated increases in NO signaling in rpWAT and induces molecular and structural fingerprints of rpWAT browning. The results endorse l-arginine as a pharmaceutical alternative to cold exposure, which could be of great interest in obesity and associated metabolic diseases.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofPharmaceuticsen_US
dc.subjectNitric oxideen_US
dc.subjectL-arginineen_US
dc.subjectBrowningen_US
dc.titlel-Arginine Induces White Adipose Tissue Browning—A New Pharmaceutical Alternative to Colden_US
dc.typeArticleen_US
dc.identifier.doi10.3390/pharmaceutics14071368-
dc.description.rankM21aen_US
dc.description.impact7.227en_US
dc.description.startpage1368en_US
dc.description.volume14en_US
dc.description.issue7en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.orcid0000-0002-3044-9963-
crisitem.author.orcid0000-0001-5272-579X-
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