Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/4587
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kalezic, Andjelika | en_US |
dc.contributor.author | Korać, Aleksandra | en_US |
dc.contributor.author | Korać, Bato | en_US |
dc.contributor.author | Jankovic, Aleksandra. | en_US |
dc.date.accessioned | 2022-07-06T16:25:22Z | - |
dc.date.available | 2022-07-06T16:25:22Z | - |
dc.date.issued | 2022-06-28 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.uri | https://biore.bio.bg.ac.rs/handle/123456789/4587 | - |
dc.description.abstract | The beneficial effects of l-arginine supplementation in obesity and type II diabetes involve white adipose tissue (WAT) reduction and increased substrate oxidation. We aimed to test the potential of l-arginine to induce WAT browning. Therefore, the molecular basis of browning was investigated in retroperitoneal WAT (rpWAT) of rats exposed to cold or treated with 2.25% l-arginine for 1, 3, and 7 days. Compared to untreated control, levels of inducible nitric oxide (NO) synthase protein expression and NO signaling increased in both cold-exposed and l-arginine-treated groups. These increases coincided with the appearance of multilocular adipocytes and increased expression levels of uncoupling protein 1 (UCP1), thermogenic and beige adipocyte-specific genes (Cidea, Cd137, and Tmem26), mitochondriogenesis markers (peroxisome proliferator-activated receptor (PPAR)-γ coactivator-1α, mitochondrial DNA copy number), nuclear respiratory factor 1, PPARα and their respective downstream lipid oxidation enzymes after l-arginine treatment. Such browning phenotype in the l-arginine-treated group was concordant with end-course decreases in leptinaemia, rpWAT mass, and body weight. In conclusion, l-arginine mimics cold-mediated increases in NO signaling in rpWAT and induces molecular and structural fingerprints of rpWAT browning. The results endorse l-arginine as a pharmaceutical alternative to cold exposure, which could be of great interest in obesity and associated metabolic diseases. | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartof | Pharmaceutics | en_US |
dc.subject | Nitric oxide | en_US |
dc.subject | L-arginine | en_US |
dc.subject | Browning | en_US |
dc.title | l-Arginine Induces White Adipose Tissue Browning—A New Pharmaceutical Alternative to Cold | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.3390/pharmaceutics14071368 | - |
dc.description.rank | M21a | en_US |
dc.description.impact | 7.227 | en_US |
dc.description.startpage | 1368 | en_US |
dc.description.volume | 14 | en_US |
dc.description.issue | 7 | en_US |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Chair of Cell and Tissue Biology | - |
crisitem.author.orcid | 0000-0002-3044-9963 | - |
crisitem.author.orcid | 0000-0001-5272-579X | - |
Appears in Collections: | Journal Article |
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