Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4560
Title: Late-Onset Calorie Restriction Worsens Cognitive Performances and Increases Frailty Level in Female Wistar Rats
Authors: Prvulovic, Milica
Milanovic , Desanka
Vujović, Predrag 
Jovic, Milena
Kanazir, Selma
Todorovic, Smilja
Mladenovic, Aleksandra
Keywords: Aging;Healthspan;Memory;Nutrition;Sex
Issue Date: 23-Nov-2021
Rank: M21
Publisher: Oxford University Press
Citation: Milica R Prvulovic, MSc, Desanka J Milanovic, PhD, Predrag Z Vujovic, PhD, Milena S Jovic, MSc, Selma D Kanazir, PhD, Smilja T Todorovic, PhD, Aleksandra N Mladenovic, PhD, Late-Onset Calorie Restriction Worsens Cognitive Performances and Increases Frailty Level in Female Wistar Rats, The Journals of Gerontology: Series A, 2021;, glab353, https://doi.org/10.1093/gerona/glab353
Journal: Journals of Gerontology. Series A: Biological Sciences and Medical Sciences
Abstract: 
The current study aims to determine the potential benefits of calorie restriction (CR), one of the most promising paradigms for life span and healthspan extension, on cognitive performances in female Wistar rats during aging. As a measure of a healthspan, we evaluated the effects of different onset and duration of CR on frailty level. Female Wistar rats were exposed to either ad libitum (AL) or CR (60% of AL daily intake) food intake during aging. Two different CR protocols were used, life-long CR with an early-onset that started at the adult stage (6 months) and 3-month-long CR, started at the middle (15 months) and late-middle (21 months) age, thus defined as a late-onset CR. The effects of CR were evaluated using open-field, Y-maze, and novel object recognition tests. We broadened 2 tools for frailty assessment currently in use for experimental animals, and in alignment with our previous study, we created a physical-cognitive frailty tool that combines both physical and cognitive performances. Our results clearly showed that CR effects are highly dependent on CR duration and onset. While a life-long restriction with an early-onset has been proven as protective and beneficial, short-term restriction introduced at late age significantly worsens an animal's behavior and frailty. These results complement our previous study conducted in males and contribute to the understanding of sex differences in a response to CR during aging.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4560
ISSN: 1758-535X
1079-5006
DOI: 10.1093/gerona/glab353
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