Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4560
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dc.contributor.authorPrvulovic, Milicaen_US
dc.contributor.authorMilanovic , Desankaen_US
dc.contributor.authorVujović, Predragen_US
dc.contributor.authorJovic, Milenaen_US
dc.contributor.authorKanazir, Selmaen_US
dc.contributor.authorTodorovic, Smiljaen_US
dc.contributor.authorMladenovic, Aleksandraen_US
dc.date.accessioned2022-03-24T17:21:38Z-
dc.date.available2022-03-24T17:21:38Z-
dc.date.issued2021-11-23-
dc.identifier.citationMilica R Prvulovic, MSc, Desanka J Milanovic, PhD, Predrag Z Vujovic, PhD, Milena S Jovic, MSc, Selma D Kanazir, PhD, Smilja T Todorovic, PhD, Aleksandra N Mladenovic, PhD, Late-Onset Calorie Restriction Worsens Cognitive Performances and Increases Frailty Level in Female Wistar Rats, The Journals of Gerontology: Series A, 2021;, glab353, https://doi.org/10.1093/gerona/glab353en_US
dc.identifier.issn1758-535X-
dc.identifier.issn1079-5006-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/4560-
dc.description.abstractThe current study aims to determine the potential benefits of calorie restriction (CR), one of the most promising paradigms for life span and healthspan extension, on cognitive performances in female Wistar rats during aging. As a measure of a healthspan, we evaluated the effects of different onset and duration of CR on frailty level. Female Wistar rats were exposed to either ad libitum (AL) or CR (60% of AL daily intake) food intake during aging. Two different CR protocols were used, life-long CR with an early-onset that started at the adult stage (6 months) and 3-month-long CR, started at the middle (15 months) and late-middle (21 months) age, thus defined as a late-onset CR. The effects of CR were evaluated using open-field, Y-maze, and novel object recognition tests. We broadened 2 tools for frailty assessment currently in use for experimental animals, and in alignment with our previous study, we created a physical-cognitive frailty tool that combines both physical and cognitive performances. Our results clearly showed that CR effects are highly dependent on CR duration and onset. While a life-long restriction with an early-onset has been proven as protective and beneficial, short-term restriction introduced at late age significantly worsens an animal's behavior and frailty. These results complement our previous study conducted in males and contribute to the understanding of sex differences in a response to CR during aging.en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofJournals of Gerontology. Series A: Biological Sciences and Medical Sciencesen_US
dc.subjectAgingen_US
dc.subjectHealthspanen_US
dc.subjectMemoryen_US
dc.subjectNutritionen_US
dc.subjectSexen_US
dc.titleLate-Onset Calorie Restriction Worsens Cognitive Performances and Increases Frailty Level in Female Wistar Ratsen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/gerona/glab353-
dc.description.rankM21en_US
dc.description.impact6.356en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.orcid0000-0002-9444-4758-
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