Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4559
Title: Antioxidant defense system in the prefrontal cortex of chronically stressed rats treated with lithium
Authors: Gavrilović, Ljubica
Popović, Nataša
Stojiljković, Vesna
Pejić, Snežana
Todorović, Ana
Vujović, Predrag 
Pajović, Snežana
Keywords: Antioxidant enzymes;prefrontal cortex;Lithium;Chronic restraint stress;Rats
Issue Date: 23-Mar-2022
Rank: M22
Publisher: PeerJ
Citation: Gavrilović L, Popović N, Stojiljković V, Pejić S, Todorović A, Vujović P, Pajović SB. 2022. Antioxidant defense system in the prefrontal cortex of chronically stressed rats treated with lithium. PeerJ 10:e13020 DOI 10.7717/peerj.13020
Journal: PeerJ
Abstract: 
Background
This study aimed to investigate the effects of lithium treatment on gene expression and activity of the prefrontal antioxidant enzymes: copper, zinc superoxide dismutase (SOD1), manganes superoxide dismutase (SOD2), catalase (CAT), and glutathione peroxidase (GPx) in animals exposed to chronic restraint stress (CRS).
Methods
The investigated parameters were quantified using real-time RT-PCR, Western blot analyses, and assays of enzyme activities.
Results
We found that lithium treatment decreased gene expression of SOD2, as well as the activities of SOD1 and SOD2 in chronically stressed rats to the levels found in unstressed animals. However, lithium treatment in animals exposed to CRS increased prefrontal GPx activity to the levels found in unstressed animals.

Conclusions
These findings confirm that treatment with lithium induced the modulation of prefrontal antioxidant status in chronically stressed rats. Our results may be very important in biomedical research for understanding the role of lithium in maintaining the stability of prefrontal antioxidant defense system in neuropsychiatric disorders caused by chronic stress.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4559
ISSN: 2167-8359
DOI: 10.7717/peerj.13020
Appears in Collections:Journal Article

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