Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4500
Title: Fructose‐rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression
Authors: Dakić, Tamara 
Lakić, Iva 
Zec, Manja
Takic, Marija
Stojiljkovic, Mojca
Jevđović, Tanja 
Keywords: fructose;glucose transporters;hippocampus;hypothalamus;walnut
Issue Date: 1-Nov-2021
Rank: M21
Journal: Journal of the Science of Food and Agriculture
Abstract: 
Background: Nutritional modulations may be considered a strategy to protect mental health. Neuronal homeostasis is highly dependent on the availability of glucose, which represents the primary energy source for the brain. In this study, we evaluated the effects of walnut intake and fructose-rich diet on the expression of glucose transporters (GLUTs) in two rat brain regions: hypothalamus and hippocampus.
Results: Our results show that walnut supplementation of fructose-fed animals restored the hypothalamic content of GLUT1 and GLUT3 protein. Furthermore, walnut intake did not affect increased hypothalamic GLUT2 content upon fructose consumption. These effects were accompanied by distinctive alterations of hippocampal GLUTs levels. Specifically, walnut intake increased GLUT1 content, whereas GLUT2 protein was decreased within the rat hippocampus after both individual and combined treatments.
Conclusion: Overall, our study suggests that walnut supplementation exerted modulatory effects on the glucose transporters within specific brain regions in the presence of developed metabolic disorder. © 2021 Society of Chemical Industry.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4500
ISSN: 0022-5142
1097-0010
DOI: 10.1002/jsfa.11252
Appears in Collections:Journal Article

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