Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4152
Title: Oxidative Stress Parameters in Goitrogen-Exposed Crested Newt Larvae (Triturus spp.): Arrested Metamorphosis
Authors: Gavrić, Jelena P.
Despotović, Svetlana G.
Gavrilović, Branka R.
Radovanović, Tijana B.
Petrović, Tamara G.
Ajduković, Maja
Vučić, Tijana 
Cvijanović, Milena
Faggio, Caterina
Prokić, Marko D.
Keywords: Thiourea;Thyroid hormones;Metamorphosis;Antioxidative compounds;Amphibians
Issue Date: 2021
Rank: M21
Project: 451-03-9/2021-14/200007
451-03-9/2021-14/200178
Journal: International Journal of Environmental Research and Public Health
Abstract: 
Thiourea is an established disruptor of thyroid hormone synthesis and is frequently used as an inhibitor of metamorphosis. The changes caused by thiourea can affect processes associated with the oxidative status of individuals (metabolic rate, the HPI axis, antioxidant system). We investigated the parameters of oxidative stress in crested newt (Triturus spp.) larvae during normal development in late larval stage 62 and newly metamorphosed individuals, and during thiourea-stimulated metamorphosis arrest in individuals exposed to low (0.05%) and high (0.1%) concentrations of thiourea. Both groups of crested newts exposed to thiourea retained their larval characteristics until the end of the experiment. The low activities of antioxidant enzymes and the high lipid peroxidation level pointed to increased oxidative stress in larvae at the beginning of stage 62 as compared to fully metamorphosed individuals. The activities of catalase (CAT) and glutathione-S-transferase (GST) and the concentration of sulfhydryl (SH) groups were significantly lower in larvae reared in aqueous solutions containing thiourea than in newly metamorphosed individuals. The high thiourea concentration (0.1%) affected the antioxidative parameters to the extent that oxidative damage could not be avoided, contrary to a lower concentration. Our results provide a first insight into the physiological adaptations of crested newts during normal development and simulated metamorphosis arrest
URI: https://biore.bio.bg.ac.rs/handle/123456789/4152
ISSN: 1660-4601
DOI: 10.3390/ijerph18189653
Appears in Collections:Journal Article

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