Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4152
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dc.contributor.authorGavrić, Jelena P.en_US
dc.contributor.authorDespotović, Svetlana G.en_US
dc.contributor.authorGavrilović, Branka R.en_US
dc.contributor.authorRadovanović, Tijana B.en_US
dc.contributor.authorPetrović, Tamara G.en_US
dc.contributor.authorAjduković, Majaen_US
dc.contributor.authorVučić, Tijanaen_US
dc.contributor.authorCvijanović, Milenaen_US
dc.contributor.authorFaggio, Caterinaen_US
dc.contributor.authorProkić, Marko D.en_US
dc.date.accessioned2021-09-29T18:01:55Z-
dc.date.available2021-09-29T18:01:55Z-
dc.date.issued2021-
dc.identifier.issn1660-4601-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/4152-
dc.description.abstractThiourea is an established disruptor of thyroid hormone synthesis and is frequently used as an inhibitor of metamorphosis. The changes caused by thiourea can affect processes associated with the oxidative status of individuals (metabolic rate, the HPI axis, antioxidant system). We investigated the parameters of oxidative stress in crested newt (Triturus spp.) larvae during normal development in late larval stage 62 and newly metamorphosed individuals, and during thiourea-stimulated metamorphosis arrest in individuals exposed to low (0.05%) and high (0.1%) concentrations of thiourea. Both groups of crested newts exposed to thiourea retained their larval characteristics until the end of the experiment. The low activities of antioxidant enzymes and the high lipid peroxidation level pointed to increased oxidative stress in larvae at the beginning of stage 62 as compared to fully metamorphosed individuals. The activities of catalase (CAT) and glutathione-S-transferase (GST) and the concentration of sulfhydryl (SH) groups were significantly lower in larvae reared in aqueous solutions containing thiourea than in newly metamorphosed individuals. The high thiourea concentration (0.1%) affected the antioxidative parameters to the extent that oxidative damage could not be avoided, contrary to a lower concentration. Our results provide a first insight into the physiological adaptations of crested newts during normal development and simulated metamorphosis arresten_US
dc.language.isoenen_US
dc.relation451-03-9/2021-14/200007en_US
dc.relation451-03-9/2021-14/200178en_US
dc.relation.ispartofInternational Journal of Environmental Research and Public Healthen_US
dc.subjectThioureaen_US
dc.subjectThyroid hormonesen_US
dc.subjectMetamorphosisen_US
dc.subjectAntioxidative compoundsen_US
dc.subjectAmphibiansen_US
dc.titleOxidative Stress Parameters in Goitrogen-Exposed Crested Newt Larvae (Triturus spp.): Arrested Metamorphosisen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijerph18189653-
dc.description.rankM21-
dc.description.impact3.789-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Morphology, Systematics and Phylogeny of Animals-
crisitem.author.orcid0000-0002-8850-5251-
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