Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/352
Title: Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk
Authors: Kujundzic, Bojan
Zeljić, Katarina 
Supic, Gordana
Magic, Marko
Stanimirovic, Dragan
Ilic, Vesna
Jovanovic, Barbara
Magic, Zvonko
Keywords: CYP24A1;CYP27B1;MTHFR;Oral lichen planus;Single nucleotide polymorphisms;VDR
Issue Date: 1-May-2016
Journal: Clinical Oral Investigations
Abstract: 
© 2015, Springer-Verlag Berlin Heidelberg. Objectives: The current study investigated the association between VDR EcoRV (rs4516035), FokI (rs2228570), ApaI (rs7975232) and TaqI (rs731236), CYP27B1 (rs4646536), CYP24A1 (rs2296241), and MTHFR (rs1801133) gene polymorphisms and risk of oral lichen planus (OLP) occurrence. Materials and methods: The study group consisted of 65 oral lichen planus patients and 100 healthy blood donors in the control group. Single nucleotide polymorphisms were genotyped by real time PCR or PCR-restriction fragment length polymorphism (RFLP) method. Results: Heterozygous as well as mutated genotype of vitamin D receptor (VDR) FokI (rs2228570) polymorphism was associated with increased oral lichen planus risk in comparison with wild type genotype (odds ratio (OR) = 3.877, p = 0.017, OR = 38.153, p = 0.001, respectively). A significantly decreased OLP risk was observed for heterozygous genotype of rs2296241 polymorphism in CYP24A1 gene compared with the wild type form (OR = 0.314, p = 0.012). VDR gene polymorphisms ApaI and TaqI were in linkage disequilibrium (D’ = 0.71, r 2  = 0.22). Identified haplotype AT was associated with decreased OLP risk (OR = 0.592, p = 0.047). Conclusion: Our results highlight the possible important role of VDR FokI (rs2228570) and CYP24A1 rs2296241 gene polymorphisms for oral lichen planus susceptibility. Clinical relevance: Identification of new molecular biomarkers could potentially contribute to determination of individuals with OLP predisposition.
URI: https://biore.bio.bg.ac.rs/handle/123456789/352
ISSN: 1432-6981
DOI: 10.1007/s00784-015-1572-7
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