Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/352
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dc.contributor.authorKujundzic, Bojanen_US
dc.contributor.authorZeljić, Katarinaen_US
dc.contributor.authorSupic, Gordanaen_US
dc.contributor.authorMagic, Markoen_US
dc.contributor.authorStanimirovic, Draganen_US
dc.contributor.authorIlic, Vesnaen_US
dc.contributor.authorJovanovic, Barbaraen_US
dc.contributor.authorMagic, Zvonkoen_US
dc.date.accessioned2019-07-01T11:48:03Z-
dc.date.available2019-07-01T11:48:03Z-
dc.date.issued2016-05-01-
dc.identifier.issn1432-6981-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/352-
dc.description.abstract© 2015, Springer-Verlag Berlin Heidelberg. Objectives: The current study investigated the association between VDR EcoRV (rs4516035), FokI (rs2228570), ApaI (rs7975232) and TaqI (rs731236), CYP27B1 (rs4646536), CYP24A1 (rs2296241), and MTHFR (rs1801133) gene polymorphisms and risk of oral lichen planus (OLP) occurrence. Materials and methods: The study group consisted of 65 oral lichen planus patients and 100 healthy blood donors in the control group. Single nucleotide polymorphisms were genotyped by real time PCR or PCR-restriction fragment length polymorphism (RFLP) method. Results: Heterozygous as well as mutated genotype of vitamin D receptor (VDR) FokI (rs2228570) polymorphism was associated with increased oral lichen planus risk in comparison with wild type genotype (odds ratio (OR) = 3.877, p = 0.017, OR = 38.153, p = 0.001, respectively). A significantly decreased OLP risk was observed for heterozygous genotype of rs2296241 polymorphism in CYP24A1 gene compared with the wild type form (OR = 0.314, p = 0.012). VDR gene polymorphisms ApaI and TaqI were in linkage disequilibrium (D’ = 0.71, r 2  = 0.22). Identified haplotype AT was associated with decreased OLP risk (OR = 0.592, p = 0.047). Conclusion: Our results highlight the possible important role of VDR FokI (rs2228570) and CYP24A1 rs2296241 gene polymorphisms for oral lichen planus susceptibility. Clinical relevance: Identification of new molecular biomarkers could potentially contribute to determination of individuals with OLP predisposition.en_US
dc.language.isoenen_US
dc.relation.ispartofClinical Oral Investigationsen_US
dc.subjectCYP24A1en_US
dc.subjectCYP27B1en_US
dc.subjectMTHFRen_US
dc.subjectOral lichen planusen_US
dc.subjectSingle nucleotide polymorphismsen_US
dc.subjectVDRen_US
dc.titleAssociation of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risken_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s00784-015-1572-7-
dc.identifier.pmid26303648-
dc.identifier.scopus2-s2.0-84939825746-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/84939825746-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Genetics and Evolution-
crisitem.author.orcid0000-0002-3906-7785-
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