Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/341
Title: The role of hypothalamic catecholamines in stress hormone release in rats exposed to acute cold
Authors: Jasnić, Nebojša 
Vujović, Predrag 
Lakić, Iva 
Đorđević, Jelena 
Đurašević, Siniša 
Dronjak-Čučaković, Slađana
Cvijić, Gordana
Keywords: Cold stress;Catecholamines;Hypothalamus
Issue Date: 10-Sep-2010
Conference: International symposium “One hundred years of Ivan Djaja’s (Jean Giaja) Belgrade school of physiology”
Abstract: 
The parvocellular neurons of the hypothalamic paraventricular nucleus
(PVN) are under the catecholaminergic influence of the medial preoptic area
(MPOA) which is supposed to be the thermoregulation centre. About 50% of
PVN parvocellular neurons coexpress vasopressin (VP) and corticotrophin-releasing
hormone (CRH), which have synergistic action on adrenocorticotropic
hormone (ACTH) secretion. Consequent rise in blood corticosterone (CORT)
levels is the key for successful coping with that threat. The aim of this study was
to reveal the correlation among aforementioned hormones and neurotransmitters
after exposure to cold for different periods of time. The Rattus norvegicus
(Wistar strain), were exposed to cold (+4°C) for a 30 or 60 min. The circulating
hormones were determined by an ELISA test (CORT, VP), chemiluminescence’s
method (ACTH) or radioenzymatic assay (catecholamines). The pituitary morphology
was examined by fluorescent immunohistochemistry. The results obtained
show the decrease in hypothalamic catecholamine levels after exposure
to cold regardless of the exposure duration, unlike the ACTH levels which were
increased, being higher after 30 min of exposure than after 60 min. The blood
CORT concentrations followed the ACTH changes. The blood VP levels were
statistically unchanged in comparison to control, regardless of the exposure duration.
Those results suggest that catecholamines are not the only neurotransmitters
involved in regulation of HPA activity, since their pattern of changes is
different from those of ACTH.
URI: https://biore.bio.bg.ac.rs/handle/123456789/341
Appears in Collections:Conference abstract

Files in This Item:
File Description SizeFormat Existing users please
2010.pdf1.19 MBAdobe PDF
    Request a copy
Show full item record

Page view(s)

1
checked on Nov 4, 2024

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.