Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/330
Title: Vasopressin turnover in the hypothalamus of rats exposed to low and high ambient temperature
Authors: Jasnić, Nebojša 
Dakić, Tamara 
Bataveljić, Danijela
Vujović, Predrag 
Lakić, Iva 
Đurašević, Siniša 
Đorđević, Jelena 
Cvijić, Gordana
Keywords: Vasopressin;Hypothalamus;Ambient temperature
Issue Date: 15-Jul-2013
Conference: 10th World Congress on Neurohypophysial Hormones
Abstract: 
Thermal stressors such as low and high ambient temperature elicit an abundance of
neuroendocrine responses including activation of the hypothalamo-pituitary-adrenal
(HPA) axis, and arginine-vasopressin (AVP) release (1, 2). The exposure to heat,
unlike cold, represents not only an unpleasant experience, but a threat to the osmotic
homeostasis as well. Since AVP has long been recognized as a hormone involved in
the modulation of HPA axis activity (3), along with its well known peripheral effects,
the aim of this study was to elucidate the hypothalamic AVP turnover in acutely heat
and cold exposed rats. Rats were exposed to high (38°C) or low (4°C) ambient
temperature for 60 minutes. Western blot was employed for determination of
hypothalamic AVP levels, and difference in AVP content between supraoptic (SON)
and paraventricular nucleus (PVN) was detected using immunohistochemical
analysis. The obtained results show that both exposure to high and low ambient
temperature increased hypothalamic AVP level, although with different intensity since
the level was higher under heat conditions. On the other hand, pattern of AVP level
changes in PVN and SON was stressor-specific, given that cold exposure mainly
increased the SON AVP level, while heat exposure affected the PVN AVP content
more. In conclusion, our results directly confirmed the positive correlation between
temperature stressors and changes in hypothalamic AVP content, rising new
questions about the origin of AVP secreted during various and often different needs
of the organism.
URI: https://biore.bio.bg.ac.rs/handle/123456789/330
Appears in Collections:Conference abstract

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