Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/2704
Title: Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata
Authors: Novakovic, Miroslav
Bukvički, Danka 
Andjelkovic, Boban
Ilic-Tomic, Tatjana
Veljić, Milan 
Tesevic, Vele
Asakawa, Yoshinori
Issue Date: 26-Apr-2019
Rank: M21a
Journal: Journal of Natural Products
Abstract: 
© 2019 American Chemical Society and American Society of Pharmacognosy. Seven new bisbibenzyls (1-7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1-7 were elucidated on the basis of the spectroscopic data. These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzyls, perrottetins (1-3), and the cyclic analogues, riccardins (4-7). Besides standard perrottetin and riccardin structures (1 and 4, respectively), they contain phenanthrene (3 and 5), dihydrophenanthrene (2), and quinone moieties (6 and 7), rarely found in natural products. The new compounds 3 and 5, as well as the known riccardin G, exhibited cytotoxic activity against the A549 lung cancer cell line with IC50 values of 5.0, 5.0, and 2.5 μM, respectively.
URI: https://biore.bio.bg.ac.rs/handle/123456789/2704
ISSN: 0163-3864
DOI: 10.1021/acs.jnatprod.8b00390
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