Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/1884
Title: | The effect of simvastatin in pancreas of diabetic rats | Authors: | Stančić, A Korać, Aleksandra Otašević, Vesna Janković, A Korać, Bato |
Keywords: | Statins;Diabetes;Insulin;β-cell;regeneration | Issue Date: | 2018 | Rank: | M52 | Publisher: | Društvo za ishranu Srbije | Journal: | Hrana i ishrana | Abstract: | Growing evidences suggest that statins exert several cholesterol-independent pleiotropic effects in diabetes, but there is no consensus whether they are positive or negative. To shed more light on this issue, we examined the effect of simvastatin on β-cell regeneration in a diabetic state. Diabetes was induced in male Mill Hill rats with a single alloxan dose (120 mg/kg). Both non-diabetic and diabetic groups were additionally separated into two subgroups: treated with simvastatin (5 mg/kg/day, i.g., 12 days) and control. Treatment of diabetic animals started after diabetes induction (glucose level ≥ 12 mmol/L). Our findings revealed that there is no increase in the area of insulin-immunopositive cells neither normalization of serum insulin level after simvastatin treatment of diabetic animals, although simvastatin increased nuclear immunopositivity for pancreas duodenum homeobox-1 (PDX-1) and proliferating cell nuclear antigen (PCNA). The data from this study suggest that 12-day treatment with simvastatin did not improve diabetes- induced disturbances in β-cell mass/function. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/1884 |
Appears in Collections: | Journal Article |
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.