Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1884
DC FieldValueLanguage
dc.contributor.authorStančić, Aen_US
dc.contributor.authorKorać, Aleksandraen_US
dc.contributor.authorOtašević, Vesnaen_US
dc.contributor.authorJanković, Aen_US
dc.contributor.authorKorać, Batoen_US
dc.date.accessioned2019-10-17T10:28:00Z-
dc.date.available2019-10-17T10:28:00Z-
dc.date.issued2018-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/1884-
dc.description.abstractGrowing evidences suggest that statins exert several cholesterol-independent pleiotropic effects in diabetes, but there is no consensus whether they are positive or negative. To shed more light on this issue, we examined the effect of simvastatin on β-cell regeneration in a diabetic state. Diabetes was induced in male Mill Hill rats with a single alloxan dose (120 mg/kg). Both non-diabetic and diabetic groups were additionally separated into two subgroups: treated with simvastatin (5 mg/kg/day, i.g., 12 days) and control. Treatment of diabetic animals started after diabetes induction (glucose level ≥ 12 mmol/L). Our findings revealed that there is no increase in the area of insulin-immunopositive cells neither normalization of serum insulin level after simvastatin treatment of diabetic animals, although simvastatin increased nuclear immunopositivity for pancreas duodenum homeobox-1 (PDX-1) and proliferating cell nuclear antigen (PCNA). The data from this study suggest that 12-day treatment with simvastatin did not improve diabetes- induced disturbances in β-cell mass/function.en_US
dc.language.isoenen_US
dc.publisherDruštvo za ishranu Srbijeen_US
dc.relation.ispartofHrana i ishranaen_US
dc.subjectStatinsen_US
dc.subjectDiabetesen_US
dc.subjectInsulinen_US
dc.subjectβ-cellen_US
dc.subjectregenerationen_US
dc.titleThe effect of simvastatin in pancreas of diabetic ratsen_US
dc.typeArticleen_US
dc.identifier.urlhttp://ibiss-r.rcub.bg.ac.rs/bitstream/handle/123456789/3318/HranaiIshrana_2018_59_1_19-25.pdf?sequence=1&isAllowed=y-
dc.description.rankM52en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.orcid0000-0002-3044-9963-
crisitem.author.orcid0000-0001-5272-579X-
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