Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/1884
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Stančić, A | en_US |
dc.contributor.author | Korać, Aleksandra | en_US |
dc.contributor.author | Otašević, Vesna | en_US |
dc.contributor.author | Janković, A | en_US |
dc.contributor.author | Korać, Bato | en_US |
dc.date.accessioned | 2019-10-17T10:28:00Z | - |
dc.date.available | 2019-10-17T10:28:00Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://biore.bio.bg.ac.rs/handle/123456789/1884 | - |
dc.description.abstract | Growing evidences suggest that statins exert several cholesterol-independent pleiotropic effects in diabetes, but there is no consensus whether they are positive or negative. To shed more light on this issue, we examined the effect of simvastatin on β-cell regeneration in a diabetic state. Diabetes was induced in male Mill Hill rats with a single alloxan dose (120 mg/kg). Both non-diabetic and diabetic groups were additionally separated into two subgroups: treated with simvastatin (5 mg/kg/day, i.g., 12 days) and control. Treatment of diabetic animals started after diabetes induction (glucose level ≥ 12 mmol/L). Our findings revealed that there is no increase in the area of insulin-immunopositive cells neither normalization of serum insulin level after simvastatin treatment of diabetic animals, although simvastatin increased nuclear immunopositivity for pancreas duodenum homeobox-1 (PDX-1) and proliferating cell nuclear antigen (PCNA). The data from this study suggest that 12-day treatment with simvastatin did not improve diabetes- induced disturbances in β-cell mass/function. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Društvo za ishranu Srbije | en_US |
dc.relation.ispartof | Hrana i ishrana | en_US |
dc.subject | Statins | en_US |
dc.subject | Diabetes | en_US |
dc.subject | Insulin | en_US |
dc.subject | β-cell | en_US |
dc.subject | regeneration | en_US |
dc.title | The effect of simvastatin in pancreas of diabetic rats | en_US |
dc.type | Article | en_US |
dc.identifier.url | http://ibiss-r.rcub.bg.ac.rs/bitstream/handle/123456789/3318/HranaiIshrana_2018_59_1_19-25.pdf?sequence=1&isAllowed=y | - |
dc.description.rank | M52 | en_US |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Chair of Cell and Tissue Biology | - |
crisitem.author.orcid | 0000-0002-3044-9963 | - |
crisitem.author.orcid | 0000-0001-5272-579X | - |
Appears in Collections: | Journal Article |
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