Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/160
Title: The role of nitric oxide in diabetic skin (patho)physiology
Authors: Stancic, Ana
Jankovic, Aleksandra
Korać, Aleksandra 
Buzadzic, Biljana
Otasevic, Vesna
Korać, Bato 
Keywords: Diabetes;L-Arginine;Nitric oxide;Skin;SOD mimic
Issue Date: 1-Jun-2018
Rank: M21
Journal: Mechanisms of Ageing and Development
Abstract: 
The role of nitric oxide ([rad]NO) in cutaneous physiology/pathology became a growing research field since the discovery that almost all types of skin cells can synthetize this redox signaling molecule about 20 years ago. Now, it is evident that [rad]NO is an important player in skin physiological processes and in responses of cutaneous cells to external insults, while the impaired [rad]NO signaling has an important consequence in skin pathology. Skin disorders are common complications in diabetic conditions. Various metabolic/biochemical and immunological dysregulations in diabetic skin are tightly coupled with the disturbances in the redox state, primarily the ratio between [rad]NO and superoxide (О2[rad]−). This review describes possible therapeutic significance of different redox state modulators in the treatment of diabetic skin disorders. The focus is on those modulators that tightly control [rad]NO/О2[rad]− ratio through the complex mechanisms affecting endogenous [rad]NO and О2[rad]− producing and removing systems. The fact that classic antioxidants failed to show significant benefits in diabetes, emphasizes the importance of such redox mechanism-based and targeted approaches.
URI: https://biore.bio.bg.ac.rs/handle/123456789/160
ISSN: 0047-6374
DOI: 10.1016/j.mad.2017.08.018
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