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Title: | The role of nitric oxide in diabetic skin (patho)physiology | Authors: | Stancic, Ana Jankovic, Aleksandra Korać, Aleksandra Buzadzic, Biljana Otasevic, Vesna Korać, Bato |
Keywords: | Diabetes;L-Arginine;Nitric oxide;Skin;SOD mimic | Issue Date: | 1-Jun-2018 | Rank: | M21 | Journal: | Mechanisms of Ageing and Development | Abstract: | The role of nitric oxide ([rad]NO) in cutaneous physiology/pathology became a growing research field since the discovery that almost all types of skin cells can synthetize this redox signaling molecule about 20 years ago. Now, it is evident that [rad]NO is an important player in skin physiological processes and in responses of cutaneous cells to external insults, while the impaired [rad]NO signaling has an important consequence in skin pathology. Skin disorders are common complications in diabetic conditions. Various metabolic/biochemical and immunological dysregulations in diabetic skin are tightly coupled with the disturbances in the redox state, primarily the ratio between [rad]NO and superoxide (О2[rad]−). This review describes possible therapeutic significance of different redox state modulators in the treatment of diabetic skin disorders. The focus is on those modulators that tightly control [rad]NO/О2[rad]− ratio through the complex mechanisms affecting endogenous [rad]NO and О2[rad]− producing and removing systems. The fact that classic antioxidants failed to show significant benefits in diabetes, emphasizes the importance of such redox mechanism-based and targeted approaches. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/160 | ISSN: | 0047-6374 | DOI: | 10.1016/j.mad.2017.08.018 |
Appears in Collections: | Journal Article |
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