Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/160
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dc.contributor.authorStancic, Anaen_US
dc.contributor.authorJankovic, Aleksandraen_US
dc.contributor.authorKorać, Aleksandraen_US
dc.contributor.authorBuzadzic, Biljanaen_US
dc.contributor.authorOtasevic, Vesnaen_US
dc.contributor.authorKorać, Batoen_US
dc.date.accessioned2019-06-25T15:13:51Z-
dc.date.available2019-06-25T15:13:51Z-
dc.date.issued2018-06-01-
dc.identifier.issn0047-6374-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/160-
dc.description.abstractThe role of nitric oxide ([rad]NO) in cutaneous physiology/pathology became a growing research field since the discovery that almost all types of skin cells can synthetize this redox signaling molecule about 20 years ago. Now, it is evident that [rad]NO is an important player in skin physiological processes and in responses of cutaneous cells to external insults, while the impaired [rad]NO signaling has an important consequence in skin pathology. Skin disorders are common complications in diabetic conditions. Various metabolic/biochemical and immunological dysregulations in diabetic skin are tightly coupled with the disturbances in the redox state, primarily the ratio between [rad]NO and superoxide (О2[rad]−). This review describes possible therapeutic significance of different redox state modulators in the treatment of diabetic skin disorders. The focus is on those modulators that tightly control [rad]NO/О2[rad]− ratio through the complex mechanisms affecting endogenous [rad]NO and О2[rad]− producing and removing systems. The fact that classic antioxidants failed to show significant benefits in diabetes, emphasizes the importance of such redox mechanism-based and targeted approaches.en_US
dc.language.isoenen_US
dc.relation.ispartofMechanisms of Ageing and Developmenten_US
dc.subjectDiabetesen_US
dc.subjectL-Arginineen_US
dc.subjectNitric oxideen_US
dc.subjectSkinen_US
dc.subjectSOD mimicen_US
dc.titleThe role of nitric oxide in diabetic skin (patho)physiologyen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.mad.2017.08.018-
dc.identifier.pmid28865932-
dc.identifier.scopus2-s2.0-85029625773-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85029625773-
dc.description.rankM21-
dc.description.impact5.432-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.orcid0000-0002-3044-9963-
crisitem.author.orcid0000-0001-5272-579X-
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