Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/160
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Stancic, Ana | en_US |
dc.contributor.author | Jankovic, Aleksandra | en_US |
dc.contributor.author | Korać, Aleksandra | en_US |
dc.contributor.author | Buzadzic, Biljana | en_US |
dc.contributor.author | Otasevic, Vesna | en_US |
dc.contributor.author | Korać, Bato | en_US |
dc.date.accessioned | 2019-06-25T15:13:51Z | - |
dc.date.available | 2019-06-25T15:13:51Z | - |
dc.date.issued | 2018-06-01 | - |
dc.identifier.issn | 0047-6374 | - |
dc.identifier.uri | https://biore.bio.bg.ac.rs/handle/123456789/160 | - |
dc.description.abstract | The role of nitric oxide ([rad]NO) in cutaneous physiology/pathology became a growing research field since the discovery that almost all types of skin cells can synthetize this redox signaling molecule about 20 years ago. Now, it is evident that [rad]NO is an important player in skin physiological processes and in responses of cutaneous cells to external insults, while the impaired [rad]NO signaling has an important consequence in skin pathology. Skin disorders are common complications in diabetic conditions. Various metabolic/biochemical and immunological dysregulations in diabetic skin are tightly coupled with the disturbances in the redox state, primarily the ratio between [rad]NO and superoxide (О2[rad]−). This review describes possible therapeutic significance of different redox state modulators in the treatment of diabetic skin disorders. The focus is on those modulators that tightly control [rad]NO/О2[rad]− ratio through the complex mechanisms affecting endogenous [rad]NO and О2[rad]− producing and removing systems. The fact that classic antioxidants failed to show significant benefits in diabetes, emphasizes the importance of such redox mechanism-based and targeted approaches. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Mechanisms of Ageing and Development | en_US |
dc.subject | Diabetes | en_US |
dc.subject | L-Arginine | en_US |
dc.subject | Nitric oxide | en_US |
dc.subject | Skin | en_US |
dc.subject | SOD mimic | en_US |
dc.title | The role of nitric oxide in diabetic skin (patho)physiology | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.mad.2017.08.018 | - |
dc.identifier.pmid | 28865932 | - |
dc.identifier.scopus | 2-s2.0-85029625773 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85029625773 | - |
dc.description.rank | M21 | - |
dc.description.impact | 5.432 | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Chair of Cell and Tissue Biology | - |
crisitem.author.orcid | 0000-0002-3044-9963 | - |
crisitem.author.orcid | 0000-0001-5272-579X | - |
Appears in Collections: | Journal Article |
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