Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1545
Title: The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity
Authors: Pejin, Boris
Tešanović, Kristina 
Jakovljević, Dragica
Kaišarević, Sonja
Šibul, Filip
Rašeta, Milena
Karaman, Maja
Keywords: AChE inhibitors of natural origin not belonging to the alkaloids;Alzheimer’s disease;Mushrooms;sugars
Issue Date: 4-Mar-2019
Rank: M22
Journal: Natural Product Research
Abstract: 
© 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group. The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC 50 values of 0.62 ± 0.07 and 0.61 ± 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained β-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer’s disease.
URI: https://biore.bio.bg.ac.rs/handle/123456789/1545
ISSN: 1478-6419
DOI: 10.1080/14786419.2017.1405417
Appears in Collections:Journal Article

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