Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1545
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dc.contributor.authorPejin, Borisen_US
dc.contributor.authorTešanović, Kristinaen_US
dc.contributor.authorJakovljević, Dragicaen_US
dc.contributor.authorKaišarević, Sonjaen_US
dc.contributor.authorŠibul, Filipen_US
dc.contributor.authorRašeta, Milenaen_US
dc.contributor.authorKaraman, Majaen_US
dc.date.accessioned2019-10-08T11:43:31Z-
dc.date.available2019-10-08T11:43:31Z-
dc.date.issued2019-03-04-
dc.identifier.issn1478-6419-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/1545-
dc.description.abstract© 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group. The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC 50 values of 0.62 ± 0.07 and 0.61 ± 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained β-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer’s disease.en_US
dc.language.isoenen_US
dc.relation.ispartofNatural Product Researchen_US
dc.subjectAChE inhibitors of natural origin not belonging to the alkaloidsen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectMushroomsen_US
dc.subjectsugarsen_US
dc.titleThe polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activityen_US
dc.typeArticleen_US
dc.identifier.doi10.1080/14786419.2017.1405417-
dc.identifier.pmid29166776-
dc.identifier.scopus2-s2.0-85034782445-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85034782445-
dc.description.rankM22-
dc.description.impact2.861-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of General Physiology and Biophysics-
crisitem.author.orcid0000-0002-4975-3471-
Appears in Collections:Journal Article
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