Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/126
Title: Distinct vasopressin content in the hypothalamic supraoptic and paraventricular nucleus of rats exposed to low and high ambient temperature
Authors: Jasnić, Nebojša 
Dakić, Tamara 
Bataveljić, Danijela
Vujović, Predrag 
Lakić, Iva 
Jevđović, Tanja 
Đurašević, Siniša 
Đorđević, Jelena 
Keywords: Cold;Heat;HPA axis;Hypothalamus;Vasopressin
Issue Date: 1-Aug-2015
Journal: Journal of Thermal Biology
Abstract: 
Both high and low ambient temperature represent thermal stressors that, among other physiological responses, induce activation of the hypothalamic-pituitary-adrenal (HPA) axis and secretion of arginine-vasopressin (AVP). The exposure to heat also leads to disturbance of osmotic homeostasis. Since AVP, in addition to its well-known peripheral effects, has long been recognized as a hormone involved in the modulation of HPA axis activity, the aim of the present study was to elucidate the hypothalamic AVP amount in the acutely heat/cold exposed rats. Rats were exposed to high (+38. °C) or low (+4. °C) ambient temperature for 60. min. Western blot was employed for determining hypothalamic AVP levels, and the difference in its content between supraoptic (SON) and paraventricular nucleus (PVN) was detected using immunohistochemical analysis. The results showed that exposure to both high and low ambient temperature increased hypothalamic AVP levels, although the increment was higher under heat conditions. On the other hand, patterns of AVP level changes in PVN and SON were stressor-specific, given that exposure to cold increased the AVP level in both nuclei, while heat exposure affected the PVN AVP content alone. In conclusion, our results revealed that cold and heat stress influence hypothalamic AVP amount with different intensity. Moreover, different pattern of AVP amount changes in the PVN and SON indicates a role of this hormone not only in response to heat as an osmotic/physical threat, but to the non-osmotic stressors as well.
URI: https://biore.bio.bg.ac.rs/handle/123456789/126
ISSN: 0306-4565
DOI: 10.1016/j.jtherbio.2015.04.004
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