Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1185
Title: Interrelationship of antioxidative status, lipid peroxidation, and lipid profile in insulin-dependent and non-insulin-dependent diabetic patients
Authors: Cimbaljević, Branko
Vasilijević, Ana
Cimbaljević, Slavica
Buzadžić, Biljana
Korać, Aleksandra 
Petrović, Vesna
Janković, Aleksandra
Korać, Bato 
Keywords: Antioxidative defense;Diabetes mellitus;Erythrocytes;Lipid profile;Reactive oxygen species
Issue Date: 1-Oct-2007
Journal: Canadian Journal of Physiology and Pharmacology
Abstract: 
This study aimed to investigate the interrelationship of plasma lipid profile, lipid peroxidation, and erythrocyte antioxidative defense in patients with insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus. Plasma levels of total cholesterol, triglycerides, and lipid peroxides and the activities of copper, zinc superoxide dismutase (CuZnSOD), catalase, glutathione peroxidase (GSH-Px), as well as the amount of glutathione in erythrocytes, were determined in IDDM, NIDDM, and nondiabetic control subjects. Additionally, morphology of erythrocytes in all subjects was examined. Plasma levels of total cholesterol and triglycerides were significantly increased in NIDDM compared with controls. Also, the lipid peroxide level was higher in NIDDM than in either control or IDDM subjects. CuZnSOD activity in erythrocytes was elevated in NIDDM patients compared with the control. In NIDDM patients, more extensive erythrocyte spherocytosis and echinocytosis compared with both control and IDDM subjects were observed. In contrast with the IDDM group, the observed abnormality in lipid metabolism in NIDDM patients is closely associated with increased lipid peroxidation, changes in antioxidative defense, and erythrocyte morphology. © 2007 NRC.
URI: https://biore.bio.bg.ac.rs/handle/123456789/1185
ISSN: 0008-4212
DOI: 10.1139/Y07-088
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