Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1182
Title: l-Arginine supplementation induces glutathione synthesis in interscapular brown adipose tissue through activation of glutamate-cysteine ligase expression: The role of nitric oxide
Authors: Petrović, Vesna
Buzadžić, Biljana
Korać, Aleksandra 
Vasilijević, Ana
Janković, Aleksandra
Korać, Bato 
Keywords: Glutamate-cysteine ligase;Glutathione;IBAT;NF-κB;Nitric oxide
Issue Date: 10-Dec-2009
Project: Ministry of Science and Technological Development of the Republic of Serbia [143050]
Journal: Chemico-Biological Interactions
Abstract: 
We examined whether nitric oxide (NO) in vivo could induce interscapular brown adipose tissue (IBAT) glutathione synthesis. Data show that NO induces in vivo IBAT glutathione synthesis through activation of glutamate-cysteine ligase (GCL) mRNA and protein expression. This NO effect appeared to be mediated by nuclear factor-κB (NF-κB) activation. We have also observed a complex series of in vivo cellular responses during chronic inhibition of NO synthesis, suggesting that regulatory pathways unrelated to GCL alteration underlie glutathione level increase induced by Nω-nitro-l-arginine methyl ester (l-NAME). In general, glutathione synthesis in IBAT seemed to be finely tuned by NO to provide glutathione for either mediating the effects of NO, or for preventing potential nitrosative stress. © 2009 Elsevier Ireland Ltd. All rights reserved.
URI: https://biore.bio.bg.ac.rs/handle/123456789/1182
ISSN: 0009-2797
DOI: 10.1016/j.cbi.2009.07.010
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