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Title: | l-Arginine supplementation induces glutathione synthesis in interscapular brown adipose tissue through activation of glutamate-cysteine ligase expression: The role of nitric oxide | Authors: | Petrović, Vesna Buzadžić, Biljana Korać, Aleksandra Vasilijević, Ana Janković, Aleksandra Korać, Bato |
Keywords: | Glutamate-cysteine ligase;Glutathione;IBAT;NF-κB;Nitric oxide | Issue Date: | 10-Dec-2009 | Project: | Ministry of Science and Technological Development of the Republic of Serbia [143050] | Journal: | Chemico-Biological Interactions | Abstract: | We examined whether nitric oxide (NO) in vivo could induce interscapular brown adipose tissue (IBAT) glutathione synthesis. Data show that NO induces in vivo IBAT glutathione synthesis through activation of glutamate-cysteine ligase (GCL) mRNA and protein expression. This NO effect appeared to be mediated by nuclear factor-κB (NF-κB) activation. We have also observed a complex series of in vivo cellular responses during chronic inhibition of NO synthesis, suggesting that regulatory pathways unrelated to GCL alteration underlie glutathione level increase induced by Nω-nitro-l-arginine methyl ester (l-NAME). In general, glutathione synthesis in IBAT seemed to be finely tuned by NO to provide glutathione for either mediating the effects of NO, or for preventing potential nitrosative stress. © 2009 Elsevier Ireland Ltd. All rights reserved. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/1182 | ISSN: | 0009-2797 | DOI: | 10.1016/j.cbi.2009.07.010 |
Appears in Collections: | Journal Article |
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