Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1182
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dc.contributor.authorPetrović, Vesnaen_US
dc.contributor.authorBuzadžić, Biljanaen_US
dc.contributor.authorKorać, Aleksandraen_US
dc.contributor.authorVasilijević, Anaen_US
dc.contributor.authorJanković, Aleksandraen_US
dc.contributor.authorKorać, Batoen_US
dc.date.accessioned2019-08-16T13:00:20Z-
dc.date.available2019-08-16T13:00:20Z-
dc.date.issued2009-12-10-
dc.identifier.issn0009-2797-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/1182-
dc.description.abstractWe examined whether nitric oxide (NO) in vivo could induce interscapular brown adipose tissue (IBAT) glutathione synthesis. Data show that NO induces in vivo IBAT glutathione synthesis through activation of glutamate-cysteine ligase (GCL) mRNA and protein expression. This NO effect appeared to be mediated by nuclear factor-κB (NF-κB) activation. We have also observed a complex series of in vivo cellular responses during chronic inhibition of NO synthesis, suggesting that regulatory pathways unrelated to GCL alteration underlie glutathione level increase induced by Nω-nitro-l-arginine methyl ester (l-NAME). In general, glutathione synthesis in IBAT seemed to be finely tuned by NO to provide glutathione for either mediating the effects of NO, or for preventing potential nitrosative stress. © 2009 Elsevier Ireland Ltd. All rights reserved.en_US
dc.language.isoenen_US
dc.relationMinistry of Science and Technological Development of the Republic of Serbia [143050]en_US
dc.relation.ispartofChemico-Biological Interactionsen_US
dc.subjectGlutamate-cysteine ligaseen_US
dc.subjectGlutathioneen_US
dc.subjectIBATen_US
dc.subjectNF-κBen_US
dc.subjectNitric oxideen_US
dc.titlel-Arginine supplementation induces glutathione synthesis in interscapular brown adipose tissue through activation of glutamate-cysteine ligase expression: The role of nitric oxideen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.cbi.2009.07.010-
dc.identifier.pmid19631198-
dc.identifier.scopus2-s2.0-70350282939-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/70350282939-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.orcid0000-0002-3044-9963-
crisitem.author.orcid0000-0001-5272-579X-
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