Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/1182
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Petrović, Vesna | en_US |
dc.contributor.author | Buzadžić, Biljana | en_US |
dc.contributor.author | Korać, Aleksandra | en_US |
dc.contributor.author | Vasilijević, Ana | en_US |
dc.contributor.author | Janković, Aleksandra | en_US |
dc.contributor.author | Korać, Bato | en_US |
dc.date.accessioned | 2019-08-16T13:00:20Z | - |
dc.date.available | 2019-08-16T13:00:20Z | - |
dc.date.issued | 2009-12-10 | - |
dc.identifier.issn | 0009-2797 | - |
dc.identifier.uri | https://biore.bio.bg.ac.rs/handle/123456789/1182 | - |
dc.description.abstract | We examined whether nitric oxide (NO) in vivo could induce interscapular brown adipose tissue (IBAT) glutathione synthesis. Data show that NO induces in vivo IBAT glutathione synthesis through activation of glutamate-cysteine ligase (GCL) mRNA and protein expression. This NO effect appeared to be mediated by nuclear factor-κB (NF-κB) activation. We have also observed a complex series of in vivo cellular responses during chronic inhibition of NO synthesis, suggesting that regulatory pathways unrelated to GCL alteration underlie glutathione level increase induced by Nω-nitro-l-arginine methyl ester (l-NAME). In general, glutathione synthesis in IBAT seemed to be finely tuned by NO to provide glutathione for either mediating the effects of NO, or for preventing potential nitrosative stress. © 2009 Elsevier Ireland Ltd. All rights reserved. | en_US |
dc.language.iso | en | en_US |
dc.relation | Ministry of Science and Technological Development of the Republic of Serbia [143050] | en_US |
dc.relation.ispartof | Chemico-Biological Interactions | en_US |
dc.subject | Glutamate-cysteine ligase | en_US |
dc.subject | Glutathione | en_US |
dc.subject | IBAT | en_US |
dc.subject | NF-κB | en_US |
dc.subject | Nitric oxide | en_US |
dc.title | l-Arginine supplementation induces glutathione synthesis in interscapular brown adipose tissue through activation of glutamate-cysteine ligase expression: The role of nitric oxide | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.cbi.2009.07.010 | - |
dc.identifier.pmid | 19631198 | - |
dc.identifier.scopus | 2-s2.0-70350282939 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/70350282939 | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Chair of Cell and Tissue Biology | - |
crisitem.author.orcid | 0000-0002-3044-9963 | - |
crisitem.author.orcid | 0000-0001-5272-579X | - |
Appears in Collections: | Journal Article |
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