Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1172
Title: Correlation between sperm parameters and protein expression of antioxidative defense enzymes in seminal plasma: A pilot study
Authors: Macanovic, Biljana
Vucetic, Milica
Jankovic, Aleksandra
Stancic, Ana
Buzadzic, Biljana
Garalejic, Eliana
Korać, Aleksandra 
Korać, Bato 
Otasevic, Vesna
Issue Date: 1-Jan-2015
Rank: M22
Project: Reactive oxygen and nitrogen species functions in reproduction: possible pharmacological tools to treat human infertility 
COST [BM1203]
Journal: Disease Markers
Abstract: 
Background. Semen analysis is the cornerstone in the evaluation of male (in)fertility. However, there are men with normal semen tests but with impaired fertilizing ability, as well as fertile men with poor sperm characteristics. Thus, there is rising interest to find novel parameters that will help to predict and define the functional capacity of spermatozoa. Methods.We examined whether there is a correlation between semen parameters (count, progressive motility, and morphology) and protein expression/activity of antioxidative defense enzymes in seminal plasma from 10 normospermic subjects. Results. Sperm progressive motility was in positive correlation with seminal plasma protein expression of both superoxide dismutase (SOD) isoforms (MnSOD and CuZnSOD) and catalase. Also, positive correlation was observed between sperm count and MnSOD protein expression, as well as between spermmorphology and protein expression of catalase in seminal plasma. In contrast, protein expression of glutathione peroxidase was not in correlation with any sperm parameter, while its activity negatively correlated with sperm morphology and motility. Conclusions.These data suggest that evaluation of protein expression of antioxidative defense enzymes in seminal plasma might be of importance in the evaluation ofmale fertility status and that could be used as an additional biomarker along with classic semen analysis in assessment of semen quality.
URI: https://biore.bio.bg.ac.rs/handle/123456789/1172
ISSN: 0278-0240
DOI: 10.1155/2015/436236
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