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Title: | New insights into male (in)fertility: The importance of NO | Authors: | Buzadzic, B. Vucetic, M. Jankovic, A. Stancic, A. Korać, Aleksandra Korać, Bato Otasevic, V. |
Keywords: | acrosome reaction;capacitation;in vitro fertilization;infertility;Mitochondria;motility;Nitric oxide;Redox regulation;spermatozoa | Issue Date: | 1-Jan-2015 | Rank: | M21a | Project: | Reactive oxygen and nitrogen species functions in reproduction: possible pharmacological tools to treat human infertility White or/and brown: importance of adipose tissue in overall redox dependent metabolic control in physiological adaptations and metabolic disorders COST action [BM1005] |
Journal: | British Journal of Pharmacology | Abstract: | © 2014 The British Pharmacological Society. Infertility is a global problem that is on the rise, especially during the last decade. Currently, infertility affects approximately 10-15% of the population worldwide. The frequency and origin of different forms of infertility varies. It has been shown that reactive oxygen and nitrogen species (ROS and RNS) are involved in the aetiology of infertility, especially male infertility. Various strategies have been designed to remove or decrease the production of ROS and RNS in spermatozoa, in particular during in vitro fertilization. However, in recent years it has been shown that spermatozoa naturally produce a variety of ROS/RNS, including superoxide anion radical (O2-), hydrogen peroxide and NO. These reactive species, in particular NO, are essential in regulating sperm capacitation and the acrosome reaction, two processes that need to be acquired by sperm in order to achieve fertilization potential. In addition, it has recently been shown that mitochondrial function is positively correlated with human sperm fertilization potential and quality and that NO and NO precursors increase sperm motility by increasing energy production in mitochondria. We will review the new link between sperm NO-driven redox regulation and infertility herein. A special emphasis will be placed on the potential implementation of new redox-active substances that modulate the content of NO in spermatozoa to increase fertility and promote conception. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/1171 | ISSN: | 0007-1188 | DOI: | 10.1111/bph.12675 |
Appears in Collections: | Journal Article |
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