Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1171
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dc.contributor.authorBuzadzic, B.en_US
dc.contributor.authorVucetic, M.en_US
dc.contributor.authorJankovic, A.en_US
dc.contributor.authorStancic, A.en_US
dc.contributor.authorKorać, Aleksandraen_US
dc.contributor.authorKorać, Batoen_US
dc.contributor.authorOtasevic, V.en_US
dc.date.accessioned2019-08-16T12:10:29Z-
dc.date.available2019-08-16T12:10:29Z-
dc.date.issued2015-01-01-
dc.identifier.issn0007-1188-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/1171-
dc.description.abstract© 2014 The British Pharmacological Society. Infertility is a global problem that is on the rise, especially during the last decade. Currently, infertility affects approximately 10-15% of the population worldwide. The frequency and origin of different forms of infertility varies. It has been shown that reactive oxygen and nitrogen species (ROS and RNS) are involved in the aetiology of infertility, especially male infertility. Various strategies have been designed to remove or decrease the production of ROS and RNS in spermatozoa, in particular during in vitro fertilization. However, in recent years it has been shown that spermatozoa naturally produce a variety of ROS/RNS, including superoxide anion radical (O2-), hydrogen peroxide and NO. These reactive species, in particular NO, are essential in regulating sperm capacitation and the acrosome reaction, two processes that need to be acquired by sperm in order to achieve fertilization potential. In addition, it has recently been shown that mitochondrial function is positively correlated with human sperm fertilization potential and quality and that NO and NO precursors increase sperm motility by increasing energy production in mitochondria. We will review the new link between sperm NO-driven redox regulation and infertility herein. A special emphasis will be placed on the potential implementation of new redox-active substances that modulate the content of NO in spermatozoa to increase fertility and promote conception.en_US
dc.language.isoenen_US
dc.relationReactive oxygen and nitrogen species functions in reproduction: possible pharmacological tools to treat human infertilityen_US
dc.relationWhite or/and brown: importance of adipose tissue in overall redox dependent metabolic control in physiological adaptations and metabolic disordersen_US
dc.relationCOST action [BM1005]en_US
dc.relation.ispartofBritish Journal of Pharmacologyen_US
dc.subjectacrosome reactionen_US
dc.subjectcapacitationen_US
dc.subjectin vitro fertilizationen_US
dc.subjectinfertilityen_US
dc.subjectMitochondriaen_US
dc.subjectmotilityen_US
dc.subjectNitric oxideen_US
dc.subjectRedox regulationen_US
dc.subjectspermatozoaen_US
dc.titleNew insights into male (in)fertility: The importance of NOen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/bph.12675-
dc.identifier.pmid24601995-
dc.identifier.scopus2-s2.0-84923650701-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/84923650701-
dc.description.rankM21aen_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.orcid0000-0002-3044-9963-
crisitem.author.orcid0000-0001-5272-579X-
crisitem.project.funderMESTD-
crisitem.project.grantno173055-
crisitem.project.fundingProgramBasic Research (BR or ON)-
crisitem.project.openAireinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173055-
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