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Title: | 17β-estradiol in vitro affects Na-dependent and depolarization-induced Ca <sup>2+</sup> transport in rat brain synaptosomes | Authors: | Nikezić, G. Horvat, A. Nedeljković, Nadežda Martinović, J. V. |
Keywords: | Brain;Calcium transport;Estradiol;Rat;Synaptosomes | Issue Date: | 1-Jan-1996 | Journal: | Experientia | Abstract: | Effects of 17β-estradiol (E 2 ) in vitro on Na-dependent Ca 2+ efflux from, and depolarization-induced Ca 2+ uptake into, the nerve cell were studied with the use of synaptosomes isolated from the brain stem, mesencephalic reticular formation (MRF), caudate nucleus and the hippocampus of long-term ovariectomized adult female rats. It was found that E 2 (1) at a concentration of 10 nM or lower, stimulates Na-dependent Ca 2+ efflux in the caudate nucleus and hippocampus, and does not affect the efflux in MRF and brain stem; (2) at concentrations above 10 nM has no effect on the Ca 2+ efflux in any of the four structures investigated; and (3) produces a biphasic effect on the depolarization-induced Ca 2+ uptake, increasing it in all structures except MRF at 10 nM concentration, and decreasing it at concentrations higher than 10 nM, irrespective of the structure investigated. These results suggest that E 2 , acting at extranuclear sites, modulates synaptic transmission via alterations of Ca 2+ transport mechanisms in nerve endings. |
URI: | https://biore.bio.bg.ac.rs/handle/123456789/1127 | ISSN: | 0014-4754 | DOI: | 10.1007/BF01920709 |
Appears in Collections: | Journal Article |
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