Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1067
Title: Combined Treatment with Ribavirin and Tiazofurin att enuates response of glial cells in Experimental Autoimmune Encephalomyelitis
Authors: Savić, Danijela
Lavrnja, Irena
Dacić, Sanja 
Bjelobaba, Ivana
Nedeljković, Nadežda 
Peković, Sanja
Stojiljković, Mirjana
Keywords: Experimental autoimmune encephalomyelitis;Glial cells;Ribavirin;Tiazofurin
Issue Date: 30-Oct-2012
Journal: Archives of Biological Sciences
Abstract: 
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS), a human inflammatory and demyelinating disease. Microglia and astrocytes are glial cells of the central nervous system (CNS) that play a dual role in MS and EAE pathology. The aim of this study was to examine the effect of combined treatment with two nucleoside analogues, ribavirin and tiazofurin, on microglia and astrocytes in actively induced EAE. Therapeutic treatment with a combination of these two nucleoside analogues reduced disease severity, mononuclear cell infiltration and demyelination. The obtained histological results indicate that ribavirin and tiazofurin changed activated microglia into an inactive type and attenuated astrocyte reactivity at the end of the treatment period. Since reduction of reactive microgliosis and astrogliosis correlated with EAE suppression, the present study also suggests that the obtained beneficial effect of ribavirin and tiazofurin could be a consequence of their action inside as well as outside the CNS.
URI: https://biore.bio.bg.ac.rs/handle/123456789/1067
ISSN: 0354-4664
DOI: 10.2298/ABS1203843S
Appears in Collections:Journal Article

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