Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7257
Title: Liposomal Encapsulation of Ascorbyl Palmitate: Influence on Skin Performance
Authors: Stolić Jovanović, Aleksandra
Tadić, Vanja M
Martinović, Milica
Žugić, Ana
Nešić, Ivana
Blagojević, Stevan
Jasnić, Nebojša 
Tosti, Tomislav
Keywords: ascorbyl palmitate;cream;emulgel;liposomes;tape stripping
Issue Date: 20-Jul-2024
Rank: M21
Publisher: MDPI
Project: 451-03-65/2024-03/200113
451-03-66/2024-03/200003
451-03-68/2023-14/200003
Journal: Pharmaceutics
Volume: 16
Issue: 7
Start page: 962
Abstract: 
L-ascorbic acid represents one of the most potent antioxidant, photoprotective, anti-aging, and anti-pigmentation cosmeceutical agents, with a good safety profile. However, the main challenge is the formulation of stable topical formulation products, which would optimize the penetrability of L-ascorbic acid through the skin. The aim of our research was to evaluate the performance of ascorbyl palmitate on the skin, incorporated in creams and emulgels (2%) as carriers, as well as to determine the impact of its incorporation into liposomes on the penetration profile of this ingredient. Tape stripping was used to study the penetration of ascorbyl palmitate into the stratum corneum. In addition, the sensory and textural properties of the formulations were determined. The liposomal formulations exhibited a better penetration profile (p < 0.05) of the active substance compared to the non-liposomal counterpart, leading to a 1.3-fold and 1.2 fold-increase in the total amount of penetrated ascorbyl palmitate in the stratum corneum for the emulgel and cream, respectively. Encapsulation of ascorbyl palmitate into liposomes led to an increase in the adhesiveness and density of the prepared cream and emulgel samples. The best spreadability and absorption during application were detected in liposomal samples. The obtained results confirmed that liposomal encapsulation of ascorbyl palmitate improved dermal penetration for both the cream and emulgel formulations.
URI: https://biore.bio.bg.ac.rs/handle/123456789/7257
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics16070962
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