Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7257
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dc.contributor.authorStolić Jovanović, Aleksandraen_US
dc.contributor.authorTadić, Vanja Men_US
dc.contributor.authorMartinović, Milicaen_US
dc.contributor.authorŽugić, Anaen_US
dc.contributor.authorNešić, Ivanaen_US
dc.contributor.authorBlagojević, Stevanen_US
dc.contributor.authorJasnić, Nebojšaen_US
dc.contributor.authorTosti, Tomislaven_US
dc.date.accessioned2024-09-02T09:21:08Z-
dc.date.available2024-09-02T09:21:08Z-
dc.date.issued2024-07-20-
dc.identifier.issn1999-4923-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/7257-
dc.description.abstractL-ascorbic acid represents one of the most potent antioxidant, photoprotective, anti-aging, and anti-pigmentation cosmeceutical agents, with a good safety profile. However, the main challenge is the formulation of stable topical formulation products, which would optimize the penetrability of L-ascorbic acid through the skin. The aim of our research was to evaluate the performance of ascorbyl palmitate on the skin, incorporated in creams and emulgels (2%) as carriers, as well as to determine the impact of its incorporation into liposomes on the penetration profile of this ingredient. Tape stripping was used to study the penetration of ascorbyl palmitate into the stratum corneum. In addition, the sensory and textural properties of the formulations were determined. The liposomal formulations exhibited a better penetration profile (p < 0.05) of the active substance compared to the non-liposomal counterpart, leading to a 1.3-fold and 1.2 fold-increase in the total amount of penetrated ascorbyl palmitate in the stratum corneum for the emulgel and cream, respectively. Encapsulation of ascorbyl palmitate into liposomes led to an increase in the adhesiveness and density of the prepared cream and emulgel samples. The best spreadability and absorption during application were detected in liposomal samples. The obtained results confirmed that liposomal encapsulation of ascorbyl palmitate improved dermal penetration for both the cream and emulgel formulations.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation451-03-65/2024-03/200113en_US
dc.relation451-03-66/2024-03/200003en_US
dc.relation451-03-68/2023-14/200003en_US
dc.relation.ispartofPharmaceuticsen_US
dc.subjectascorbyl palmitateen_US
dc.subjectcreamen_US
dc.subjectemulgelen_US
dc.subjectliposomesen_US
dc.subjecttape strippingen_US
dc.titleLiposomal Encapsulation of Ascorbyl Palmitate: Influence on Skin Performanceen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.3390/pharmaceutics16070962-
dc.identifier.pmid39065659-
dc.identifier.scopus2-s2.0-85199652957-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85199652957-
dc.description.rankM21en_US
dc.description.impact4.9en_US
dc.description.startpage962en_US
dc.description.volume16en_US
dc.description.issue7en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.orcid0000-0003-0333-333X-
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