Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/7244
Title: Flaxseed Oil Alleviates Trimethyltin-Induced Cell Injury and Inhibits the Pro-Inflammatory Activation of Astrocytes in the Hippocampus of Female Rats
Authors: Mitrović, Nataša
Adžić Bukvić, Marija 
Zarić Kontić, Marina
Dragić, Milorad 
Petrović, Snježana
Paunović, Marija
Vučić, Vesna
Grković, Ivana
Keywords: Hippocampus;;Trimethyltin;;Flaxseed oil;;Alpha-linolenic acid;;Neuroinflammation;;Astrocytes;;Neuroprotection.
Issue Date: 2024
Rank: M22
Publisher: MPDI
Journal: Cells
Volume: 13
Issue: 14
Start page: 1184
Abstract: 
Exposure to the neurotoxin trimethyltin (TMT) selectively induces hippocampal neuronal injury and astrocyte activation accompanied with resultant neuroinflammation, which causes severe behavioral, cognitive, and memory impairment. A large body of evidence suggests that flaxseed oil (FSO), as one of the richest sources of essential omega-3 fatty acids, i.e., α-linolenic acids (ALA), displays neuroprotective properties. Here, we report the preventive effects of dietary FSO treatment in a rat model of TMT intoxication. The administration of FSO (1 mL/kg, orally) before and over the course of TMT intoxication (a single dose, 8 mg/kg, i.p.) reduced hippocampal cell death, prevented the activation of astrocytes, and inhibited their polarization toward a pro-inflammatory/neurotoxic phenotype. The underlying protective mechanism was delineated through the selective upregulation of BDNF and PI3K/Akt and the suppression of ERK activation in the hippocampus. Pretreatment with FSO reduced cell death and efficiently suppressed the expression of inflammatory molecules. These beneficial effects were accompanied by an increased intrahippocampal content of n-3 fatty acids. In vitro, ALA pretreatment prevented the TMT-induced polarization of cultured astrocytes towards the pro-inflammatory spectrum. Together, these findings support the beneficial neuroprotective properties of FSO/ALA against TMT-induced neurodegeneration and accompanied inflammation and hint at a promising preventive use of FSO in hippocampal degeneration and dysfunction.
URI: https://biore.bio.bg.ac.rs/handle/123456789/7244
ISSN: 2073-4409
DOI: 10.3390/cells13141184
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